INT166016

Context Info Confidence 0.76 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 4.05 Pain Relevance 1.17

cell differentiation (MCL1) nucleoplasm (MCL1) mitochondrion (MCL1) nucleus (MCL1) cytoplasm (MCL1)

Anatomy Link Frequency cleavage 2 fibroblasts 1 MCL1 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 40 99.20 aspirin 11 97.72 Osteoarthritis 21 90.44 Arthritis 27 73.36 COX-2 inhibitor 3 60.20 cINOD 4 58.36 antagonist 1 55.28 Inflammatory mediators 3 48.56 palliative 2 38.08 Kinase C 2 20.44

Disease Link Frequency Relevance Heat Apoptosis 132 99.32 Rheumatoid Arthritis 40 99.20 Osteoarthritis 21 90.44 Death 17 88.76 Cancer 39 83.60 Multiple Myeloma 3 81.60 Lung Cancer 3 79.84 Metastasis 2 77.20 Colon Cancer 2 76.08 Squamous Cell Carcinoma 3 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These findings collectively suggest that aspirin induces apoptosis in YD-8 cells and the induction may be correlated to activation of caspases, caspase-dependent Mcl-1 proteolysis, inactivation of ERK-1/2 and AKT, and activation of NF-kappaB.

Protein_catabolism (proteolysis) of Mcl-1 associated with aspirin and apoptosis

1) Confidence 0.76 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.59 Pain Relevance 0.56

Degradation of Mcl-1, e.g. by caspase-3, -8 or granzyme B-mediated cleavage [12], enables proapoptotic Bcl-2 proteins to initiate mitochondrial acitivation.

Protein_catabolism (Degradation) of Mcl-1 in cleavage

2) Confidence 0.63 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.30 Pain Relevance 0

Interestingly, Mcl-1 degradation by EGCG sensitized RA synovial fibroblasts to TNF?

Protein_catabolism (degradation) of Mcl-1 in fibroblasts associated with rheumatoid arthritis

3) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 1.85 Pain Relevance 0.59

Expression of p53, p21CIP1 & Mcl-1 and PARP cleavage were next evaluated by Western blotting (Figure 2).

Protein_catabolism (cleavage) of Mcl-1 in cleavage

4) Confidence 0.03 Published 2008 Journal Mar Drugs Section Body Doc Link PMC2630805 Disease Relevance 0.31 Pain Relevance 0.03

General Comments

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