INT166389

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 8.25
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (WT1) nucleolus (WT1) RNA binding (WT1)
nucleus (WT1) intracellular (WT1) cytoplasm (WT1)
Anatomy Link Frequency
arm 1
WT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 1 71.64 Quite High
addiction 1 49.52 Quite Low
fibrosis 1 22.44 Low Low
chemokine 8 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 302 100.00 Very High Very High Very High
Cancer 101 100.00 Very High Very High Very High
Repression 1 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 464 99.98 Very High Very High Very High
Cold Sores 432 99.84 Very High Very High Very High
Necrosis 1 98.50 Very High Very High Very High
Carcinoma 7 97.04 Very High Very High Very High
Myeloid Leukemia 41 92.56 High High
Infection 125 92.12 High High
Leukemia 14 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
WT1 is a tumor-suppressor gene that encodes a protein, which mediates transcriptional repression and interacts with p53 protein [18], product of another tumor suppressor gene, TP53, frequently deleted or mutated in many human tumors.
WT1 Binding (interacts) of associated with cancer and repression
1) Confidence 0.36 Published 2005 Journal Cytojournal Section Body Doc Link PMC555739 Disease Relevance 0.45 Pain Relevance 0
ARs of HIV acquisition associated with GUD or HSV-2 were estimated separately by study arm.
GUD Binding (associated) of in arm associated with cold sores, acquired immune deficiency syndrome or hiv infection and disease
2) Confidence 0.33 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2771764 Disease Relevance 1.79 Pain Relevance 0
Other covariates significantly associated with lower symptomatic GUD were having no sex partners during the follow-up interval (PRR?
GUD Binding (associated) of associated with disease
3) Confidence 0.30 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2771764 Disease Relevance 0.98 Pain Relevance 0
PR1 responses have been investigated in a study that combined vaccination with WT1 and PR1 peptides [81].
WT1 Binding (vaccination) of
4) Confidence 0.29 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896720 Disease Relevance 0.55 Pain Relevance 0
We also estimated the attributable risk (AR) of incident HIV associated with GUD or HSV-2 using the formula [20], where exposure is GUD or HSV-2 seroconversion, respectively.
GUD Binding (associated) of associated with cold sores, acquired immune deficiency syndrome or hiv infection and disease
5) Confidence 0.29 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2771764 Disease Relevance 1.96 Pain Relevance 0
In a multivariate model, adjusted for age, number of sexual partners, and condom use, the PRR of GUD associated with circumcision was 0.54 (95% CI 0.44–0.66).
GUD Binding (associated) of associated with disease
6) Confidence 0.29 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2771764 Disease Relevance 0.99 Pain Relevance 0
Histological findings showed necrosis and spindle tumor cells which were positive for AE1/AE3 and vimentin, and negative for calretinin, D2-40, and WT-1.
WT-1 Binding (negative) of associated with necrosis and cancer
7) Confidence 0.17 Published 2010 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 20163019 Disease Relevance 1.53 Pain Relevance 0.07

General Comments

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