INT166625

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 1.91 Pain Relevance 1.00

Golgi apparatus (Acer3) endoplasmic reticulum (Acer3) transmembrane transport (Trpa1)

Acer3 (Mus musculus) Trpa1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pain 8 100.00 ASIC 2 99.36 imagery 2 97.12 diabetic neuropathy 4 90.84 Neuropathic pain 2 71.12 burning pain 2 68.52 qutenza 2 64.56 TRP channel 4 61.24

Disease Link Frequency Relevance Heat Pain 6 100.00 Nociception 8 98.16 Diabetic Neuropathy 2 90.84 Hyperglycemia 2 88.96 Hypoxia 4 88.24 Diabetes Mellitus 4 75.60 Syndrome 2 71.52 Neuropathic Pain 2 71.12 Peripheral Neuropathy 2 66.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We found that alkaline pH activates TRPA1 and that the TRPA1 activation is involved in nociception, using Ca(2+)-imaging and patch-clamp methods.

alkaline pH Positive_regulation (activates) of TRPA1 associated with nociception and imagery

1) Confidence 0.01 Published 2010 Journal Yakugaku Zasshi Section Abstract Doc Link 20190512 Disease Relevance 1.13 Pain Relevance 0.64

These results suggest that alkaline pH causes pain sensation through activation of TRPA1.

alkaline pH Positive_regulation (activation) of TRPA1 associated with pain

2) Confidence 0.00 Published 2010 Journal Yakugaku Zasshi Section Abstract Doc Link 20190512 Disease Relevance 0.78 Pain Relevance 0.37

General Comments

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