INT16686

Context Info Confidence 0.09 First Reported 1988 Last Reported 1991 Negated 1 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.26 Pain Relevance 1.68

isomerase activity (Pdia4) endoplasmic reticulum (Pdia4)

Anatomy Link Frequency myocytes 1 Pdia4 (Mus musculus)

Pain Link Frequency Relevance Heat Morphine 11 100.00 Enkephalin 6 92.76 opioid receptor 1 88.64 agonist 1 84.44 Bioavailability 1 81.60 narcan 3 75.00 anesthesia 2 75.00 lidocaine 2 66.64

Disease Link Frequency Relevance Heat Hypotension 2 99.20 Ocular Hypertension 2 85.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the second, the effect of morphine on Cai of isolated ventricular myocytes from rats which had received chronic daily injection of morphine for two weeks or myocytes which had been incubated in a solution with morphine for 12 hr was studied.

Regulation (effect) of Cai in myocytes associated with morphine

1) Confidence 0.09 Published 1991 Journal Life Sci. Section Abstract Doc Link 1847734 Disease Relevance 0 Pain Relevance 1.44

This did not affect the permeability and activity of other, more lipophilic, CAI like methazolamide and ethoxzolamide (E).

Neg (not) Regulation (affect) of CAI

2) Confidence 0.01 Published 1988 Journal J Ocul Pharmacol Section Abstract Doc Link 3171330 Disease Relevance 0.26 Pain Relevance 0.24

General Comments

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