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Context Info
Confidence 0.62
First Reported 1991
Last Reported 2010
Negated 7
Speculated 8
Reported most in Abstract
Documents 64
Total Number 72
Disease Relevance 22.23
Pain Relevance 33.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
neuronal 7
brain 5
neurons 4
spinal 3
striatum 2
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 163 100.00 Very High Very High Very High
fluoxetine 138 100.00 Very High Very High Very High
antidepressant 92 100.00 Very High Very High Very High
withdrawal 83 100.00 Very High Very High Very High
Morphine 55 100.00 Very High Very High Very High
cocaine 45 100.00 Very High Very High Very High
bDMF 43 100.00 Very High Very High Very High
Locus ceruleus 21 100.00 Very High Very High Very High
monoamine 13 100.00 Very High Very High Very High
adenocard 5 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 452 99.82 Very High Very High Very High
Nociception 92 99.52 Very High Very High Very High
Urological Neuroanatomy 203 99.48 Very High Very High Very High
Morphine Dependence 3 99.40 Very High Very High Very High
Death 215 99.16 Very High Very High Very High
Neurodegenerative Disease 85 99.10 Very High Very High Very High
Depression 77 99.08 Very High Very High Very High
Diabetes Mellitus 450 98.48 Very High Very High Very High
Intellectual Impairment 1 97.84 Very High Very High Very High
Cognitive Disorder 82 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CREB protein levels were not altered by acute or chronic morphine.
Neg (not) Regulation (altered) of CREB associated with morphine
1) Confidence 0.62 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12969258 Disease Relevance 0.07 Pain Relevance 1.39
Intrathecal treatment with a CaM kinase II inhibitor, KN-93, significantly blocked the increased phosphorylation of CREB, but did not affect the CREB protein itself.
Neg (not) Regulation (affect) of CREB associated with intrathecal
2) Confidence 0.61 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15631885 Disease Relevance 0 Pain Relevance 0.52
Our previous findings reported the role of nitric oxide system and CaM kinase II in the CREB regulation [13,25].
Regulation (regulation) of CREB
3) Confidence 0.60 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0.09 Pain Relevance 0.55
It is well known that the dopamine and cAMP-regulated phosphoprotein (DARPP-32), via activation, is converted into a potent inhibitor of protein phosphatase-1 (PP-1), which regulates the activity of CREB.
Regulation (regulates) of CREB associated with dopamine
4) Confidence 0.60 Published 2007 Journal Brain Res. Section Abstract Doc Link 17125745 Disease Relevance 0 Pain Relevance 0.32
Here we investigated the alterations on phospho-Ser133 CREB, phospho-Thr34 DARPP-32 and phospho-Thr75 DARPP-32 induced by continuous infusions of cocaine, GBR12909, fluoxetine and nisoxetine.
Spec (investigated) Regulation (alterations) of CREB associated with fluoxetine and cocaine
5) Confidence 0.60 Published 2007 Journal Brain Res. Section Abstract Doc Link 17125745 Disease Relevance 0 Pain Relevance 0.59
Although forskolin did not alter CREB-IR, forskolin did induce striatal P-CREB-IR and Fos-IR by 2.5- and 10-fold, respectively.
Neg (not) Regulation (alter) of CREB
6) Confidence 0.58 Published 1994 Journal Neuroreport Section Abstract Doc Link 7919167 Disease Relevance 0 Pain Relevance 0.14
Our findings showed a significant down regulation of CREB in cerebral cortex and cerebellum of diabetic rats, when compared to control.
Regulation (regulation) of CREB in cerebellum associated with diabetes mellitus and cerebral cortex
7) Confidence 0.57 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890658 Disease Relevance 0.60 Pain Relevance 0.54
This investigation examined the effects of acute and chronic ethanol exposure and its withdrawal on the cAMP-responsive element binding protein (CREB) and the activator protein-1 (AP-1) gene transcription factors in the rat brain.
Spec (examined) Regulation (effects) of cAMP-responsive element binding protein in brain associated with withdrawal
8) Confidence 0.57 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918601 Disease Relevance 0.18 Pain Relevance 0.20
This investigation examined the effects of acute and chronic ethanol exposure and its withdrawal on the cAMP-responsive element binding protein (CREB) and the activator protein-1 (AP-1) gene transcription factors in the rat brain.
Spec (examined) Regulation (effects) of CREB in brain associated with withdrawal
9) Confidence 0.57 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9918601 Disease Relevance 0.18 Pain Relevance 0.20
Antidepressants and prolonged stress in rats modulate CAM-L1, laminin, and pCREB, implicated in neuronal plasticity.
Regulation (modulate) of pCREB in neuronal associated with stress and antidepressant
10) Confidence 0.55 Published 2005 Journal Neurobiol. Dis. Section Title Doc Link 15905095 Disease Relevance 0.46 Pain Relevance 0.12
Neither an orchidectomy nor 17beta-estradiol treatment affected the pCREB response in male rats.
Neg (Neither) Regulation (affected) of pCREB
11) Confidence 0.54 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19968712 Disease Relevance 0.35 Pain Relevance 0.19
Interestingly, the increases in immunoreactivity for CREB and phosphorylated CREB (p-CREB) in the spinal dorsal horn occur 24 hr, but not 1 week, after the second injection of acidic saline compared with pH 7.2 intramuscular injections.
Regulation (immunoreactivity) of CREB in spinal associated with spinal dorsal horn
12) Confidence 0.45 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12843242 Disease Relevance 0.49 Pain Relevance 0.51
Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors.
Regulation (regulation) of cAMP response element-binding protein in neuronal associated with locus ceruleus, opiate and withdrawal
13) Confidence 0.45 Published 2006 Journal J. Neurosci. Section Title Doc Link 16641242 Disease Relevance 0 Pain Relevance 0.80
The present study further investigated the effect of antidepressant fluoxetine on the ERK-CREB signal system and the depressive-like behaviors in rats.
Regulation (effect) of CREB associated with antidepressant, depression and fluoxetine
14) Confidence 0.45 Published 2008 Journal Neurobiol. Dis. Section Abstract Doc Link 18586506 Disease Relevance 0.59 Pain Relevance 0.55
Since multiple cAMP response element (CRE) sequences are present on the prodynorphin gene promoter, the aim of our study was to investigate the effects of cocaine and monoaminergic uptake inhibitors on CREB and DARPP-32 phosphorylation and moreover the possible correlation with the changes already observed on prodynorphin gene expression.
Spec (investigate) Regulation (effects) of CREB associated with monoamine and cocaine
15) Confidence 0.44 Published 2007 Journal Brain Res. Section Abstract Doc Link 17125745 Disease Relevance 0 Pain Relevance 0.56
Alterations of CREB and DARPP-32 phosphorylation following cocaine and monoaminergic uptake inhibitors.
Regulation (Alterations) of CREB associated with monoamine and cocaine
16) Confidence 0.44 Published 2007 Journal Brain Res. Section Title Doc Link 17125745 Disease Relevance 0 Pain Relevance 0.40
This study has shown that estrogens can rapidly activate signaling pathways associated with CREB-mediated transcriptional regulation in sensory neurons.
Regulation (regulation) of CREB in sensory neurons
17) Confidence 0.43 Published 2004 Journal Neuroscience Section Abstract Doc Link 15541884 Disease Relevance 0.71 Pain Relevance 0.38
In addition, as we have shown that the factor mediating the trophic actions of VIP acts via protein kinase A we have also examined the contribution of CREB, which is a transcription factor activated by protein kinase A.
Spec (examined) Regulation (contribution) of CREB
18) Confidence 0.41 Published 2000 Journal Brain Res. Section Abstract Doc Link 10841885 Disease Relevance 0.09 Pain Relevance 0.17
It also indirectly suggests that the effect of 5-HT4 agonists on pCREB formation might not result from a dual action, namely a direct stimulation of the 5-HT4 receptors located on pyramidal neurons in addition to a global facilitation of 5-HT function, as previously proposed [37].
Regulation (effect) of pCREB in pyramidal neurons associated with pyramidal cell and agonist
19) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821932 Disease Relevance 0 Pain Relevance 0.25
In the present study, we hypothesized that the regulation of CAM-L1, laminin, and CREB/pCREB by NE could mediate processes of plasticity in the mode of action of antidepressants, as well as in the long-term effects of stress, in rats, given the association of both with NE alterations and neuronal plasticity.
Regulation (regulation) of CREB in neuronal associated with stress and antidepressant
20) Confidence 0.40 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15905095 Disease Relevance 0.48 Pain Relevance 0.15

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