INT167164

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.20
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ING1) cell cycle (ING1)
Anatomy Link Frequency
neutrophils 4
ING1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ketamine 20 99.82 Very High Very High Very High
Inflammatory stimuli 2 46.04 Quite Low
Analgesic 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 2 99.52 Very High Very High Very High
INFLAMMATION 2 45.72 Quite Low
Stress 2 45.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, ketamine racemes inhibited fMLP-induced superoxide anion generation and p47(phox) phosphorylation by modulating fMLP-mediated p38 MAPK activation in neutrophils.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of p47 in neutrophils associated with ketamine
1) Confidence 0.33 Published 2010 Journal Clin. Exp. Immunol. Section Abstract Doc Link 20345980 Disease Relevance 0.10 Pain Relevance 0.37
Interestingly, treatment with SB203580, the p38 MAPK inhibitor, also mitigated fMLP-induced superoxide anion generation and p38 MAPK and p47(phox) phosphorylation as well as apoptosis in a concentration-dependent fashion in neutrophils.
Negative_regulation (mitigated) of Phosphorylation (phosphorylation) of p47 in neutrophils associated with apoptosis
2) Confidence 0.33 Published 2010 Journal Clin. Exp. Immunol. Section Abstract Doc Link 20345980 Disease Relevance 0.10 Pain Relevance 0.40

General Comments

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