INT1672

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Context Info
Confidence 0.67
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 3.39
Pain Relevance 13.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Mtr) intracellular (Mtr) cytoplasm (Mtr)
Anatomy Link Frequency
plasma 2
brain 2
spleen 2
gland 2
thymus 1
Mtr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 83 100.00 Very High Very High Very High
withdrawal 7 99.84 Very High Very High Very High
narcan 31 99.40 Very High Very High Very High
Morphine 55 99.28 Very High Very High Very High
Neuritis 8 98.96 Very High Very High Very High
analgesia 2 98.28 Very High Very High Very High
midbrain 4 97.88 Very High Very High Very High
imagery 2 97.28 Very High Very High Very High
Hippocampus 2 95.40 Very High Very High Very High
medulla 2 91.60 High High
Disease Link Frequency Relevance Heat
Convulsion 6 99.78 Very High Very High Very High
Stress 7 99.50 Very High Very High Very High
Optic Neuritis 8 99.44 Very High Very High Very High
Fever 3 99.44 Very High Very High Very High
Drug-induced Liver Injury 8 98.44 Very High Very High Very High
Drug Induced Neurotoxicity 2 87.80 High High
Demyelinating Disease 5 86.88 High High
Aids-related Complex 2 78.72 Quite High
Congenital Anomalies 3 76.40 Quite High
Cancer 2 75.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that increased plasma-to-brain transfer of methionine enkephalin does not occur in this model of acute toxic hepatitis.
Gene_expression (transfer) of methionine enkephalin in plasma associated with drug-induced liver injury and enkephalin
1) Confidence 0.67 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1436641 Disease Relevance 0.33 Pain Relevance 0.68
In order to determine whether acute toxic hepatitis in the rat is associated with an accumulation of methionine enkephalin in plasma and increased blood-to-brain transfer of methionine enkephalin, immunoreactive methionine enkephalin levels were determined by radioimmunoassay in plasma, cerebrospinal fluid and whole brain samples from rats with thioacetamide induced acute toxic hepatitis.
Gene_expression (transfer) of methionine enkephalin in plasma associated with drug-induced liver injury and enkephalin
2) Confidence 0.52 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1436641 Disease Relevance 0.27 Pain Relevance 0.57
There was no significant difference in the percentage of grey matter between patients and controls in the regions of abnormal MTR detected in the visual cortex.
Gene_expression (detected) of MTR in cortex
3) Confidence 0.52 Published 2006 Journal Brain Section Abstract Doc Link 16495327 Disease Relevance 0.60 Pain Relevance 0.44
Prenatal stress alters the hypothalamic levels of methionine-enkephalin in pup rats.
Gene_expression (levels) of methionine-enkephalin associated with stress and enkephalin
4) Confidence 0.52 Published 1992 Journal Neuropeptides Section Title Doc Link 1454153 Disease Relevance 0.52 Pain Relevance 0.41
Levels of methionine-enkephalin in the pituitary gland of U-50,488H-tolerant-dependent or abstinent rats were unchanged.
Gene_expression (Levels) of methionine-enkephalin in pituitary gland associated with enkephalin
5) Confidence 0.48 Published 1994 Journal Pharmacology Section Abstract Doc Link 8177908 Disease Relevance 0 Pain Relevance 0.98
Magnetization transfer imaging is an MRI technique that provides quantitative information about in vivo tissue integrity, including myelin and axonal content, and is expressed as the magnetization transfer ratio (MTR).
Gene_expression (expressed) of MTR associated with imagery
6) Confidence 0.25 Published 2007 Journal Mult. Scler. Section Abstract Doc Link 17468442 Disease Relevance 0.32 Pain Relevance 0.37
Hyperthermia-induced seizures alter the levels of methionine-enkephalin in immature rat brain.
Gene_expression (levels) of methionine-enkephalin in brain associated with convulsion, enkephalin and fever
7) Confidence 0.19 Published 1992 Journal Neuropeptides Section Title Doc Link 1630599 Disease Relevance 0.64 Pain Relevance 0.20
Methionine-enkephalin (0.2--20 microgram/rat) and leucine-enkephalin (1--20 microgram/rat) produced a dose-related and naloxone-antagonizable analgesia in the tail-pinch test, when microinjected into the nucleus reticularis gigantocellularis (NRGC) and nucleus reticularis paragigantocellularis (NRPG) of the medulla oblongata of the rat.
Gene_expression (produced) of Methionine-enkephalin in medulla oblongata associated with medulla, narcan, enkephalin and analgesia
8) Confidence 0.17 Published 1978 Journal Eur. J. Pharmacol. Section Abstract Doc Link 658122 Disease Relevance 0 Pain Relevance 0.87
The effect of chronic administration of morphine and abrupt and naloxone-precipitated withdrawal on the levels of beta-endorphin and methionine-enkephalin in spleen, adrenals and thymus glands of Sprague-Dawley rats was determined.
Gene_expression (levels) of methionine-enkephalin in spleen associated with narcan, enkephalin, withdrawal and morphine
9) Confidence 0.10 Published 1989 Journal Life Sci. Section Abstract Doc Link 2533311 Disease Relevance 0 Pain Relevance 0.80
The weights of the tissues under any of the above treatments did not change nor did the levels of methionine-enkephalin and beta-endorphin in adrenals.
Gene_expression (levels) of methionine-enkephalin associated with enkephalin
10) Confidence 0.10 Published 1989 Journal Life Sci. Section Abstract Doc Link 2533311 Disease Relevance 0 Pain Relevance 1.23
The level of beta-endorphin was elevated in the spleen and thymus of morphine tolerant-dependent rats, while the levels of methionine-enkephalin in rats undergoing abrupt or naloxone-precipitated abstinence were significantly higher than in their respective placebo controls.
Gene_expression (levels) of methionine-enkephalin in thymus associated with narcan, enkephalin and morphine
11) Confidence 0.09 Published 1989 Journal Life Sci. Section Abstract Doc Link 2533311 Disease Relevance 0 Pain Relevance 1.37
The levels of methionine-enkephalin in the thymus gland of rats with placebo and morphine pellets left intact did not differ.
Gene_expression (levels) of methionine-enkephalin in gland associated with enkephalin and morphine
12) Confidence 0.09 Published 1989 Journal Life Sci. Section Abstract Doc Link 2533311 Disease Relevance 0 Pain Relevance 1.43
During abrupt and naloxone-precipitated abstinence, the levels of methionine-enkephalin in the thymus gland are significantly elevated possibly due to an inhibition of their release.
Gene_expression (levels) of methionine-enkephalin in gland associated with narcan and enkephalin
13) Confidence 0.09 Published 1989 Journal Life Sci. Section Abstract Doc Link 2533311 Disease Relevance 0 Pain Relevance 1.28
Selective protection of methionine enkephalin released from brain slices by enkephalinase inhibition.
Gene_expression (protection) of methionine enkephalin in brain associated with enkephalin
14) Confidence 0.08 Published 1981 Journal Science Section Title Doc Link 7015510 Disease Relevance 0 Pain Relevance 0.70
While the loss of TH following GMA-MS was transient, a sustained loss (34%) was observed in the midbrain 105 days after cessation of MMA-HS exposure.
Gene_expression (following) of GMA-MS in midbrain associated with midbrain
15) Confidence 0.04 Published 2010 Journal Arch. Toxicol. Section Abstract Doc Link 20224926 Disease Relevance 0.57 Pain Relevance 0.33
The level of beta-endorphin was elevated in the spleen and thymus of morphine tolerant-dependent rats, while the levels of methionine-enkephalin in rats undergoing abrupt or naloxone-precipitated abstinence were significantly higher than in their respective placebo controls.
Gene_expression (levels) of methionine-enkephalin in spleen associated with narcan, enkephalin and morphine
16) Confidence 0.03 Published 1989 Journal Life Sci. Section Abstract Doc Link 2533311 Disease Relevance 0 Pain Relevance 1.37
Methionine enkephalin is hydrolyzed by aminopeptidase N on CD4+ and CD8+ spleen T cells.
Gene_expression (hydrolyzed) of Methionine enkephalin in T cells associated with enkephalin
17) Confidence 0.01 Published 1994 Journal Arch. Biochem. Biophys. Section Title Doc Link 7910448 Disease Relevance 0 Pain Relevance 0.20
Methionine-enkephalin and alpha-endorphin were not major products in the intermediate lobe cells.
Gene_expression (products) of Methionine-enkephalin in lobe associated with enkephalin
18) Confidence 0.01 Published 1979 Journal J. Biol. Chem. Section Abstract Doc Link 224038 Disease Relevance 0.14 Pain Relevance 0.10

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