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Context Info
Confidence 0.16
First Reported 1991
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SPTA1) cytoplasm (SPTA1)
SPTA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 1 99.20 Very High Very High Very High
opioid receptor 2 75.00 Quite High
sodium channel 1 75.00 Quite High
tetrodotoxin 1 70.56 Quite High
Potency 1 41.36 Quite Low
Enkephalin 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Muscle Weakness 1 94.04 High High
Tics 1 84.28 Quite High
Hyperkalemic Periodic Paralysis 1 75.00 Quite High
Hyperkalemia 1 59.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus the dominant expression of HPP is manifest by inactivation of the wild-type Na+ channel through the influence of the mutant gene product on membrane voltage.
Gene_expression (expression) of HPP
1) Confidence 0.16 Published 1991 Journal Neuron Section Abstract Doc Link 1849724 Disease Relevance 0.23 Pain Relevance 0.16
Also examined were analogues in which tyrosine was replaced with either trans-3-(4'-hydroxyphenyl)proline (t-Hpp) or cis-3-(4'-hydroxyphenyl)proline (c-Hpp), residues in which rotations about C alpha-C beta, but not C beta-C gamma, are restricted.
Gene_expression (residues) of c-Hpp
2) Confidence 0.01 Published 1994 Journal J. Med. Chem. Section Abstract Doc Link 7996549 Disease Relevance 0.08 Pain Relevance 0.07

General Comments

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