INT167317

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Context Info
Confidence 0.34
First Reported 2006
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.35
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2RY1) aging (P2RY1) plasma membrane (P2RY1)
signal transducer activity (P2RY1)
Anatomy Link Frequency
platelet 2
skin 1
P2RY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 56 99.78 Very High Very High Very High
cva 3 93.40 High High
acular 2 88.72 High High
agonist 10 68.32 Quite High
Inflammation 11 36.12 Quite Low
chemokine 2 13.04 Low Low
antagonist 39 5.00 Very Low Very Low Very Low
Bioavailability 9 5.00 Very Low Very Low Very Low
ischemia 8 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 10 98.36 Very High Very High Very High
Cv General 3 Under Development 4 93.40 High High
Myocardial Infarction 14 92.60 High High
Fever 2 90.76 High High
Atherosclerosis 35 82.92 Quite High
Disease 8 78.92 Quite High
Rupture 2 56.60 Quite High
Polycystic Ovary Syndrome 3 56.20 Quite High
Cardiovascular Disease 7 50.00 Quite Low
Hyperlipidemia 1 40.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of the most important factors is still the second ADP receptor, P2Y1, that remains totally unaffected by clopidogrel.
Neg (unaffected) Negative_regulation (unaffected) of P2Y1
1) Confidence 0.34 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0.08 Pain Relevance 0.15
This study suggests that the residual 2MeS-ADP platelet reactivity after clopidogrel treatment is in part due to an inadequate antagonistic effect of clopidogrel on the P2Y12 receptor and partly due to the P2Y1 receptor, which is unaffected by clopidogrel.
Neg (unaffected) Negative_regulation (unaffected) of P2Y1 in platelet
2) Confidence 0.34 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0.11 Pain Relevance 0.03
One of the most important factors is still the second ADP receptor, P2Y1, that remains totally unaffected by clopidogrel.
Neg (unaffected) Negative_regulation (unaffected) of ADP receptor
3) Confidence 0.34 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0.08 Pain Relevance 0.15
We hypothesized that, similar to ASA, specific platelet ADP receptor inhibition with clopidogrel would attenuate reflex vasodilation in middle-aged skin.
Negative_regulation (inhibition) of platelet ADP receptor in skin associated with aspirin and increased venous pressure under development
4) Confidence 0.28 Published 2010 Journal J. Appl. Physiol. Section Abstract Doc Link 20360429 Disease Relevance 0.44 Pain Relevance 0.33
Clopidogrel inhibits platelet function by inhibition of ADP receptor.
Negative_regulation (inhibition) of ADP receptor in platelet
5) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.64 Pain Relevance 0.16

General Comments

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