INT167392

Context Info Confidence 0.21 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.93 Pain Relevance 0.36

nucleus (Gins4) cytoplasm (Gins4)

Anatomy Link Frequency medial 1 Gins4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat medulla 17 98.96 GABAergic 1 96.24 Locus ceruleus 16 82.24 Glutamate 1 57.52 agonist 2 56.72 cINOD 1 44.80 parabrachial 4 5.00 isoflurane 3 5.00 Central grey 2 5.00 cerebral cortex 1 5.00

Disease Link Frequency Relevance Heat Death 1 99.12 Stress 5 94.80 Injury 6 78.56 Necrosis 1 55.04 Cancer 1 54.68 Hepatotoxicity 2 51.72 INFLAMMATION 1 44.56 Muscle Hypertonia 14 11.12 Body Weight 5 5.00 Sleep Disorders 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Either antioxidant tempol or a pancaspase inhibitor Z-VAD-FMK decreased cell death as well as caspase 3/7 activity induced by SLD sulfide/TNF coexposure.

Gene_expression (coexposure) of SLD associated with death

1) Confidence 0.21 Published 2010 Journal Toxicology Section Abstract Doc Link 20371263 Disease Relevance 0.93 Pain Relevance 0

Moreover, it was demonstrated that the SLD projects to neurons in the medial medulla that also stain positively for glycine [44].

Gene_expression (projects) of SLD in medial associated with medulla

2) Confidence 0.03 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1079781 Disease Relevance 0 Pain Relevance 0.36

General Comments

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