INT167600

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Context Info
Confidence 0.72
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 2.40
Pain Relevance 5.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrm5) plasma membrane (Chrm5) signal transducer activity (Chrm5)
Anatomy Link Frequency
substantia nigra pars compacta 3
dopamine neurons 2
ventral 2
bladder 1
DRG 1
Chrm5 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 2 99.98 Very High Very High Very High
Dopamine 192 99.84 Very High Very High Very High
addiction 496 99.52 Very High Very High Very High
Cannabinoid receptor 8 99.36 Very High Very High Very High
Substantia nigra 24 98.40 Very High Very High Very High
cannabis 192 98.12 Very High Very High Very High
Ventral tegmentum 16 97.00 Very High Very High Very High
midbrain 12 93.76 High High
Nicotine 168 93.08 High High
alcohol 204 91.28 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 218 99.96 Very High Very High Very High
Drug Dependence 76 99.52 Very High Very High Very High
Overactive Bladder 6 88.08 High High
Psychosis 4 84.72 Quite High
Morphine Dependence 4 82.00 Quite High
Cannabis Dependence 72 71.12 Quite High
Nicotine Addiction 152 65.84 Quite High
Sprains And Strains 16 63.04 Quite High
Frailty 8 57.76 Quite High
Alcohol Addiction 56 51.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The localized expression of M5 receptors [28] on ventral tegmental dopamine neurons may underly the importance of M5 receptors in the male-female interaction associated male USVs.
Gene_expression (expression) of M5 in dopamine neurons associated with dopamine
1) Confidence 0.72 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 0.38 Pain Relevance 0.41
M5 muscarinic receptors are preferentially expressed on tegmental dopaminergic neurons, whereas M2 muscarinic receptors are widely expressed, especially on cholinergic cells and terminals [24], [26]–[29].
Gene_expression (expressed) of M5 in dopaminergic neurons
2) Confidence 0.72 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 0.10 Pain Relevance 0.19
In Silico analysis of the CHRM5 locus
Gene_expression (locus) of CHRM5
3) Confidence 0.66 Published 2007 Journal BMC Genet Section Body Doc Link PMC1978498 Disease Relevance 0.05 Pain Relevance 0.37
As with M5R, the nAChR are co-expressed on dopamine neurones of the SNc and VTA [12].
Gene_expression (expressed) of M5R associated with dopamine
4) Confidence 0.59 Published 2007 Journal BMC Genet Section Body Doc Link PMC1978498 Disease Relevance 0.56 Pain Relevance 1.09
The M5R is the only muscarinic receptor subtype expressed in the ventral tegmetal area (VTA) and substantia nigra pars compacta (SNc) [1-3], where it is co-localised with dopamine D2 receptors on dopaminergic neurones [1].
Gene_expression (expressed) of M5R in substantia nigra pars compacta associated with dopamine and substantia nigra
5) Confidence 0.59 Published 2007 Journal BMC Genet Section Body Doc Link PMC1978498 Disease Relevance 0 Pain Relevance 0.38
The M5 muscarinic receptor (M5R) is expressed in dopamine-containing neurones of the substantia nigra pars compacta and ventral tegmental area, and regulates the release of mesolimbic dopamine.
Gene_expression (expressed) of M5 muscarinic receptor in ventral associated with ventral tegmentum, dopamine and substantia nigra
6) Confidence 0.59 Published 2007 Journal BMC Genet Section Abstract Doc Link PMC1978498 Disease Relevance 0 Pain Relevance 0.52
The M5 muscarinic receptor (M5R) is expressed in dopamine-containing neurones of the substantia nigra pars compacta and ventral tegmental area, and regulates the release of mesolimbic dopamine.
Gene_expression (expressed) of M5R in ventral associated with ventral tegmentum, dopamine and substantia nigra
7) Confidence 0.59 Published 2007 Journal BMC Genet Section Abstract Doc Link PMC1978498 Disease Relevance 0 Pain Relevance 0.52
Genotyping of CHRM5 polymorphisms
Gene_expression (polymorphisms) of CHRM5
8) Confidence 0.58 Published 2007 Journal BMC Genet Section Body Doc Link PMC1978498 Disease Relevance 0.10 Pain Relevance 0.10
In this study, we measured the roles of these muscarinic receptors on USVs in M2, M4 and M5 knockout and wild-type mice.
Gene_expression (roles) of M5 associated with targeted disruption
9) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 0.28 Pain Relevance 0.25
We did not observe any significant differences in glutamate receptor expression levels between female M5R?
Gene_expression (expression) of M5R associated with glutamate receptor
10) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664330 Disease Relevance 0.06 Pain Relevance 0.35
RT-PCR demonstrated expression of subtypes M2R, M3R and M4R, but not of M1R and M5R, in pooled samples (30 section profiles each) of laser microdissected DiI-labelled bladder afferent cell bodies.
Gene_expression (expression) of M5R in bladder
11) Confidence 0.49 Published 2010 Journal Neuroscience Section Abstract Doc Link 20394802 Disease Relevance 0.21 Pain Relevance 0.11
Retrogradely labelled bladder afferents located in DRG L4-S2 were subjected to immunohistochemistry or to laser-assisted microdissection with subsequent RT-PCR to study expression of mAChRs subtypes M1R-M5R.
Gene_expression (expression) of M5R in DRG
12) Confidence 0.49 Published 2010 Journal Neuroscience Section Abstract Doc Link 20394802 Disease Relevance 0.23 Pain Relevance 0.13
Generation of homozygous M2, M4 and M5 receptor KO mice [genetic backgrounds: 129J1×CF1 (M2), 129/SvEv×CF1 (M4), and 129/SvEv x CD1] has been described previously [28], [68]–[70].
Gene_expression (Generation) of M5 associated with targeted disruption
13) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268741 Disease Relevance 0.44 Pain Relevance 0.04
The M5 muscarinic receptor (M5R) is expressed in dopamine-containing neurones of the substantia nigra pars compacta and ventral tegmental area, and regulates the release of mesolimbic dopamine.
Gene_expression (expressed) of M5 muscarinic receptor in substantia nigra pars compacta associated with ventral tegmentum, dopamine and substantia nigra
14) Confidence 0.20 Published 2007 Journal BMC Genet Section Abstract Doc Link PMC1978498 Disease Relevance 0 Pain Relevance 0.52
The M5 muscarinic receptor (M5R) is expressed in dopamine-containing neurones of the substantia nigra pars compacta and ventral tegmental area, and regulates the release of mesolimbic dopamine.
Gene_expression (expressed) of M5R in substantia nigra pars compacta associated with ventral tegmentum, dopamine and substantia nigra
15) Confidence 0.20 Published 2007 Journal BMC Genet Section Abstract Doc Link PMC1978498 Disease Relevance 0 Pain Relevance 0.52

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