INT167712

Context Info Confidence 0.23 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.57 Pain Relevance 0.63

nucleus (Jak1) cytoplasm (Jak1)

Anatomy Link Frequency microglia 2 Jak1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammatory response 1 98.16 Spinal cord 6 95.84 Inflammation 1 92.12 Peripheral nerve injury 3 85.64 Neuropathic pain 2 84.44 allodynia 3 75.00 cytokine 2 72.00 chemokine 1 53.04 Eae 1 45.52 Sciatic nerve 3 42.72

Disease Link Frequency Relevance Heat INFLAMMATION 2 97.80 Nervous System Injury 3 85.64 Neuropathic Pain 5 84.44 Injury 1 43.84 Hypersensitivity 1 37.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We showed recently that spinal nerve lesion leads to rapid activation of Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signal transduction pathway in dorsal spinal cord microglia in relation with enhanced levels of spinal interleukin-6 (IL-6) protein.

Positive_regulation (leads) of Positive_regulation (activation) of Janus kinase in microglia associated with spinal cord

1) Confidence 0.23 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20410127 Disease Relevance 0.57 Pain Relevance 0.63

General Comments

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