INT168101

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.04
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (PTPRF) cell adhesion (PTPRF) plasma membrane (PTPRF)
PTPRF (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 1 87.64 High High
palliative 3 83.92 Quite High
antagonist 48 79.36 Quite High
b2 receptor 16 72.04 Quite High
Antihistamine 8 68.64 Quite High
Inflammation 24 60.88 Quite High
Somatostatin 1 25.00 Low Low
bradykinin 12 14.84 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhage 4 98.56 Very High Very High Very High
Metastasis 1 97.08 Very High Very High Very High
Neuroendocrine Cancer 3 93.88 High High
Cancer 4 88.52 High High
Disease 14 76.32 Quite High
INFLAMMATION 24 60.88 Quite High
Hypersensitivity 52 50.00 Quite Low
Occupational Lung Diseases 24 46.64 Quite Low
Asthma 72 5.00 Very Low Very Low Very Low
Wheal 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Due to good differentiation (G1) a systemic biotherapy with octreotide LAR was induced.
Positive_regulation (induced) of LAR
1) Confidence 0.45 Published 2010 Journal Med. Klin. (Munich) Section Abstract Doc Link 20455052 Disease Relevance 0.98 Pain Relevance 0.13
Because these mediators are key components of allergen-induced airway responses, we wanted to determine if toxin challenge would induce a LAR and AHR similar to that seen with allergen.
Positive_regulation (induce) of LAR
2) Confidence 0.07 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257560 Disease Relevance 0.06 Pain Relevance 0.07
To determine if multiple exposures to PbTx-3 affected antigen-induced responses, we challenged sheep in the morning with 20 breaths of 100 pg/mL PbTx-3 for 3 consecutive days and then on the fourth day challenged the animals with allergen to determine if the antigen-induced EAR, LAR, and AHR were affected.
Positive_regulation (induced) of LAR
3) Confidence 0.05 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257560 Disease Relevance 0 Pain Relevance 0.11
We found that although PbTx-3 (20 breaths of 100 pg/mL) caused an early bronchoconstriction, there was no subsequent LAR or AHR in sheep that demonstrated these responses to inhaled allergen (data not shown).
Neg (no) Positive_regulation (subsequent) of LAR
4) Confidence 0.05 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257560 Disease Relevance 0 Pain Relevance 0.03
These findings indicate that, although toxin elicits an acute bronchoconstriction, the stimulus and/ or signaling mechanisms are not the same as seen with allergen that can result in a LAR and AHR.
Positive_regulation (result) of LAR
5) Confidence 0.02 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257560 Disease Relevance 0 Pain Relevance 0.03

General Comments

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