INT168138

Context Info Confidence 0.30 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.76 Pain Relevance 0.24

cellular_component (Hist2h4) biological_process (Hist2h4)

Anatomy Link Frequency embryo 3 placenta 1 Hist2h4 (Mus musculus)

Pain Link Frequency Relevance Heat headache 2 60.84 Migraine 2 60.44

Disease Link Frequency Relevance Heat Sprains And Strains 4 99.68 Manic Depressive Disorder 2 61.72 Migraine Disorders 2 60.84 Epilepsy 2 60.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We observed strain differences in acetylation of histones H3 and H4 in both embryo and placenta following in utero VPA exposure, but additional studies are needed to determine the significance of these changes in mediating teratogenesis.

Positive_regulation (following) of Localization (acetylation) of H4 in embryo associated with sprains and strains

1) Confidence 0.30 Published 2010 Journal Toxicol. Sci. Section Abstract Doc Link 20457659 Disease Relevance 0.38 Pain Relevance 0.12

We observed strain differences in acetylation of histones H3 and H4 in both embryo and placenta following in utero VPA exposure, but additional studies are needed to determine the significance of these changes in mediating teratogenesis.

Positive_regulation (following) of in placenta Localization (acetylation) of H4 in embryo associated with sprains and strains

2) Confidence 0.10 Published 2010 Journal Toxicol. Sci. Section Abstract Doc Link 20457659 Disease Relevance 0.38 Pain Relevance 0.12

General Comments

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