INT168269

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.57
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
Anatomy Link Frequency
granulosa cells 2
Ppara (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 9 100.00 Very High Very High Very High
cocaine 5 100.00 Very High Very High Very High
Cannabinoid 3 100.00 Very High Very High Very High
Ventral tegmentum 7 96.72 Very High Very High Very High
Dopamine 7 95.96 Very High Very High Very High
Morphine 4 95.52 Very High Very High Very High
agonist 10 94.92 High High
Nucleus accumbens 2 75.00 Quite High
Endocannabinoid 1 53.52 Quite High
Inflammation 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 1 93.52 High High
Breast Cancer 4 91.28 High High
Obesity 24 89.64 High High
Recurrence 1 79.00 Quite High
Cancer 6 45.04 Quite Low
Targeted Disruption 3 13.00 Low Low
Ovarian Cancer 9 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low
Reprotox - General 3 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It

is possible, however, that ICI may have directly repressed activation of PPAR?

Negative_regulation (repressed) of Positive_regulation (activation) of PPAR
1) Confidence 0.38 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.40 Pain Relevance 0.05
We found that URB597 blocked effects of nicotine and cocaine in the ShNAc through activation of both surface cannabinoid CB1-receptors and alpha-type peroxisome proliferator-activated nuclear receptor.
Negative_regulation (blocked) of Positive_regulation (activation) of alpha-type peroxisome proliferator-activated nuclear receptor associated with cannabinoid, nicotine and cocaine
2) Confidence 0.29 Published 2010 Journal Addict Biol Section Abstract Doc Link 20477753 Disease Relevance 0.08 Pain Relevance 1.75
Reduced levels of aromatase in granulosa cells after activation of PPAR?
Negative_regulation (Reduced) of Positive_regulation (activation) of PPAR in granulosa cells
3) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.09 Pain Relevance 0.08

General Comments

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