INT168383

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 17.90
Pain Relevance 6.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)
Anatomy Link Frequency
cartilage 2
MEFs 2
chondrocyte 1
IEC-6 1
spinal cord 1
Mmp13 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 159 100.00 Very High Very High Very High
Osteoarthritis 436 99.80 Very High Very High Very High
cva 14 99.66 Very High Very High Very High
Spinal cord 11 99.24 Very High Very High Very High
Arthritis 159 99.12 Very High Very High Very High
rheumatoid arthritis 85 98.76 Very High Very High Very High
chemokine 21 97.64 Very High Very High Very High
cytokine 191 97.04 Very High Very High Very High
Pain 140 95.52 Very High Very High Very High
Inflammation 507 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 229 100.00 Very High Very High Very High
Keloid Scars 100 99.92 Very High Very High Very High
Infection 152 99.84 Very High Very High Very High
Osteoarthritis 465 99.80 Very High Very High Very High
Cv General 4 Under Development 10 99.66 Very High Very High Very High
Fibrosis 197 99.28 Very High Very High Very High
Hypertrophy 21 99.18 Very High Very High Very High
Rheumatoid Arthritis 85 98.76 Very High Very High Very High
Wound Healing 88 98.32 Very High Very High Very High
Targeted Disruption 106 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Besides, PGE2, PGE1, and its analog can increase the activity of collagenase, which is lower in the supernatants from hypertrophic scar fibroblasts culture [40].
Positive_regulation (increase) of collagenase in fibroblasts associated with keloid scars
1) Confidence 0.67 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2910481 Disease Relevance 1.42 Pain Relevance 0
Moreover, our results show no overcompensatory increase in other collagenases, and even a slightly decreased collagenolytic activity in knockout mice.
Neg (no) Positive_regulation (increase) of collagenase associated with targeted disruption
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0.64 Pain Relevance 0.34
Increased collagenase activity can then weaken the tensile strength of the membranes and lower their threshold for rupture.
Positive_regulation (Increased) of collagenase associated with rupture
3) Confidence 0.67 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.10 Pain Relevance 0.41
-induced increase in collagenase activity, but only A1S2 inhibited the spontaneous collagenase activity.
Positive_regulation (increase) of collagenase
4) Confidence 0.67 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779427 Disease Relevance 0.07 Pain Relevance 0.22
In vivo, MMP-14 (MT1-MMP) and MMP-2 (gelatinase A) are two of several enzymes responsible for the activation of proMMP-13 and both are overexpressed in RA.
Positive_regulation (activation) of proMMP-13 associated with rheumatoid arthritis
5) Confidence 0.57 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.68 Pain Relevance 0.28
Briefly, the DRGs along with boundary caps were mechanically separated from the isolated spinal cord and mechanoenzymatically dissociated using Collagenase/Dispase (1 mg/ml) and DNase (0.5 mg/ml) for 30 minutes at room temperature.
Positive_regulation (using) of Collagenase in spinal cord associated with spinal cord
6) Confidence 0.49 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0 Pain Relevance 0.05
Figure 7 illustrates the changes in microglia morphology and SK3 staining after an intracerebral hemorrhage (ICH) was induced by injecting collagenase into the striatum.
Positive_regulation (injecting) of collagenase in microglia associated with cv general 4 under development and cva
7) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0.51 Pain Relevance 0.22
They found that all six compounds increased both the wound break strength and the collagenase activity.
Positive_regulation (increased) of collagenase associated with injury
8) Confidence 0.49 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2885077 Disease Relevance 1.07 Pain Relevance 0.08
Minagawa et al. [166] compared wound break strength and the increase in collagenase activity in wounds in rats after exposure to monomers, oligomers and polymers of the chitin-group (GlcNAc/N-acetylated CHOS/chitin) and the chitosan-group (GlcN/fully deacetylated CHOS/chitosan).
Positive_regulation (increase) of collagenase associated with injury
9) Confidence 0.45 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2885077 Disease Relevance 0.92 Pain Relevance 0.10
PGE1 may have a role in the prevention of hypertrophic scarring by increasing the activity of type I collagenase [29].
Positive_regulation (increasing) of collagenase associated with keloid scars
10) Confidence 0.45 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2910481 Disease Relevance 1.36 Pain Relevance 0.03
Human recombinant activated MMP-1 (collagenase) and MMP-2 (gelatinase) were used as positive controls.
Positive_regulation (activated) of collagenase
11) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0 Pain Relevance 0
RESULTS: Severe, erosive bilateral sacroiliitis in 14-week-old hTNFtg animals was accompanied by an upregulation of mRNAs related to tissue inflammation such as matrix metalloproteinase 3 (MMP3), MMP9 and MMP13 or osteoclast activation such as cathepsin K and tartrate-resistant acid phosphatase.
Positive_regulation (activation) of MMP13 in osteoclast
12) Confidence 0.31 Published 2010 Journal Ann. Rheum. Dis. Section Body Doc Link 20498200 Disease Relevance 0.38 Pain Relevance 0
Moreover, chondrocytes in OA cartilage express high levels of matrix metalloproteinase 13 (MMP-13), the enzyme most potently degrading type II collagen [6].
Positive_regulation (levels) of matrix metalloproteinase 13 in cartilage associated with metalloproteinase and osteoarthritis
13) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 1.01 Pain Relevance 0.51
Moreover, chondrocytes in OA cartilage express high levels of matrix metalloproteinase 13 (MMP-13), the enzyme most potently degrading type II collagen [6].
Positive_regulation (levels) of MMP-13 in cartilage associated with metalloproteinase and osteoarthritis
14) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 1.01 Pain Relevance 0.51
In fibrotic animals, hepatic expression of MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13 mRNA were all significantly upregulated, compared to non-fibrotic controls (Figure 6).
Positive_regulation (upregulated) of MMP-13 associated with fibrosis
15) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.32 Pain Relevance 0.06
To induce MMP-13 expression MEFs were treated for 5 hrs with 5 ng/ml PMA.


Positive_regulation (induce) of MMP-13 in MEFs
16) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.22 Pain Relevance 0.05
This underscores the hypertrophy-like character of OA chondrocytes since MMP-13 is highly upregulated during chondrocyte terminal differentiation, and deficiency of MMP-13 even results in impaired endochondral ossification [7,8].
Positive_regulation (upregulated) of MMP-13 in chondrocyte associated with hypertrophy and osteoarthritis
17) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 1.06 Pain Relevance 0.54
The latter is crucial in collagen breakdown; stromelysin seems to be pivotal in the activation of collagenase [59,60,61].
Positive_regulation (activation) of collagenase
18) Confidence 0.16 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 0.31 Pain Relevance 0.29
We also found that mRNAs encoding the matrix metalloprotease, MMP13, was induced in D21-infected lungs (Table 2).
Positive_regulation (induced) of MMP13 in lungs associated with infection
19) Confidence 0.14 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.43 Pain Relevance 0.16
Collagenase-induced chronic degenerative arthritis model
Positive_regulation (induced) of Collagenase associated with osteoarthritis and arthritis
20) Confidence 0.12 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004655 Disease Relevance 0.91 Pain Relevance 0.62

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