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Context Info
Confidence 0.73
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.75
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Nlrp3)
Anatomy Link Frequency
lower body 1
Nlrp3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 30 97.12 Very High Very High Very High
Crohn's disease 82 96.16 Very High Very High Very High
adenocard 4 91.68 High High
Inflammation 139 90.20 High High
chemokine 8 76.64 Quite High
Inflammatory response 13 72.68 Quite High
Pain 5 25.00 Low Low
ischemia 10 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
anakinra 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 119 99.20 Very High Very High Very High
Disease 121 98.76 Very High Very High Very High
Sprains And Strains 2 98.76 Very High Very High Very High
Crystal Associated Disease 82 98.46 Very High Very High Very High
Parasitemia 4 97.20 Very High Very High Very High
Infection 11 95.16 Very High Very High Very High
Syndrome 9 93.68 High High
Plasmodium Infection 17 90.84 High High
INFLAMMATION 147 90.20 High High
Targeted Disruption 13 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: The NALP3 inflammasome is a multiprotein complex that triggers caspase 1-mediated interleukin-1beta (IL-1beta) release.
Localization (release) of NALP3
1) Confidence 0.73 Published 2010 Journal Arthritis Rheum. Section Abstract Doc Link 20506209 Disease Relevance 0.17 Pain Relevance 0
The focus of this discussion is on describing diseases that are confirmed or potentially associated with the unique NLRP3 inflammasome (Fig. 1), which, in addition to stimulation by PAMPs, can also be stimulated by danger-associated molecular patterns (DAMPs) to secrete interleukin (IL)-1?
Localization (secrete) of NLRP3 associated with disease
2) Confidence 0.69 Published 2010 Journal Curr Allergy Asthma Rep Section Body Doc Link PMC2892083 Disease Relevance 0.33 Pain Relevance 0.24
This clinical and epidemiological evidence linking IBD to the MEFV gene, together with the co-localization of the MEFV and NLRP3 gene products (pyrin and NALP3, respectively) within the same signaling pathway, suggested that MEFV could also contribute to CD and/or UC susceptibility.
Localization (localization) of NALP3 associated with inflammatory bowel disease and crohn's disease
3) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.85 Pain Relevance 0.17
The group of Tschopp discovered that many inorganic particles, including MSU and calcium pyrophosphate dihydrate crystals, are capable of activating the NLRP3 inflammasome to process and secrete active IL-1?
Localization (secrete) of NLRP3 associated with crystal associated disease
4) Confidence 0.66 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.44 Pain Relevance 0.03
- and NLRP3 mice presented a slight but significant lower body temperature (Fig. 3A and 3B) and parasitemia (Fig. 3C and 3D) in the early phase of infection.
Localization (presented) of NLRP3 in lower body associated with parasitemia and infection
5) Confidence 0.53 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.95 Pain Relevance 0.14

General Comments

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