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Context Info
Confidence 0.77
First Reported 2010
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 45
Total Number 48
Disease Relevance 24.01
Pain Relevance 21.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Nnat)
Anatomy Link Frequency
neurons 5
sciatic nerve 4
pituitary gland 3
brain 2
hindbrain 2
Nnat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 771 99.88 Very High Very High Very High
dorsal root ganglion 947 99.84 Very High Very High Very High
c fibre 450 99.84 Very High Very High Very High
neuralgia 4 99.84 Very High Very High Very High
Central nervous system 45 99.68 Very High Very High Very High
Neuropathic pain 677 99.56 Very High Very High Very High
unmyelinated 270 99.56 Very High Very High Very High
Peripheral nerve injury 270 99.36 Very High Very High Very High
Hyperalgesia 270 99.06 Very High Very High Very High
chemokine 90 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 360 99.88 Very High Very High Very High
Ganglion Cysts 1352 99.84 Very High Very High Very High
Neuropathic Pain 857 99.56 Very High Very High Very High
Hyperalgesia 270 99.06 Very High Very High Very High
Adhesions 90 98.52 Very High Very High Very High
Pain 405 96.92 Very High Very High Very High
INFLAMMATION 225 96.88 Very High Very High Very High
Aging 45 95.20 Very High Very High Very High
Stress 135 92.60 High High
Neurodegenerative Disease 45 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altered neuronatin expression in the rat dorsal root ganglion after sciatic nerve transection.
Gene_expression (expression) of neuronatin in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, neuralgia and sciatic nerve
1) Confidence 0.77 Published 2010 Journal J. Biomed. Sci. Section Title Doc Link 20509861 Disease Relevance 0.10 Pain Relevance 0.46
To investigate the function of Nnat, they used recombinant adenovirus (Ad-Nnat) to overexpress the Nnat gene in primary human aortic endothelial cells (HAECs) and in the mouse aorta in vivo.
Gene_expression (overexpress) of Nnat in endothelial cells
2) Confidence 0.67 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.22 Pain Relevance 0.12
This subpopulation of primary afferent neurons demonstrated a low level of expression of Nnat in the control (Sham group) and suggests that Nnat is expressed mainly on unmyelinated C-fiber and thinly myelinated A-?
Gene_expression (expressed) of Nnat in afferent neurons associated with c fibre and unmyelinated
3) Confidence 0.67 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.79 Pain Relevance 0.86
Therefore, the scenario we speculate here is that sciatic nerve transection in adult rats might create a stressful micro-environment strong enough to trigger epigenetic modifications on the expression of Nnat, notably increasing it to a significant degree in a selective subpopulation of adult DRG neurons, specifically in sensory C and A-?
Gene_expression (expression) of Nnat in neurons associated with dorsal root ganglion and sciatic nerve
4) Confidence 0.67 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.84 Pain Relevance 0.90
To investigate whether the increased expression of Nnat found by our previous work with Affymetrix arrays was consistent with increased protein expression, left L4-L5 DRGs from 3 rats of control and experimental group (post-axotomy day 1, 3, 5, and 7) were pooled for Western blotting in triplicate (n = 9 for each group) to analyze total Nnat (Nnat-?
Gene_expression (expression) of Nnat associated with ganglion cysts
5) Confidence 0.67 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.28 Pain Relevance 0.22
In parallel studies, the expression of Nnat in DRG neurons was examined by immunofluorescence staining using frozen-cut tissues.
Spec (examined) Gene_expression (expression) of Nnat in neurons associated with dorsal root ganglion
6) Confidence 0.67 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.43 Pain Relevance 0.32
It is striking that Nnat, an imprinting gene strongly expressed mainly in neonatal developing brain, increased its expression in adult rats DRGs after axotomy of sciatic nerve.
Gene_expression (expressed) of Nnat in brain associated with ganglion cysts and sciatic nerve
7) Confidence 0.67 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 1.31 Pain Relevance 0.88
In addition, based on the Western blot results, the expression profile of total Nnat (Nnat-?
Gene_expression (expression) of Nnat
8) Confidence 0.67 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.98 Pain Relevance 0.75
Although it is not clear why Nnat expression was increased in DRG cells of axotomized rat, it is possible that a peripheral nerve injury such as axotomy of sciatic nerve, being one of the most used animal models of neuropathic pain, is able to create a "micro-environment" stress strong enough to trigger undergoing epigenetic modifications in Nnat leading to unexpected increased expression in adult DRG cells.
Gene_expression (expression) of Nnat in peripheral nerve associated with stress, dorsal root ganglion, nervous system injury, neuropathic pain, sciatic nerve and peripheral nerve injury
9) Confidence 0.67 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 1.28 Pain Relevance 0.81
The signal changes of total Nnat were expressed as 2.8, 2.5, 3.5, and 4.2 times at time points 1, 3, 5, and 7 days post-axotomy respectively compared to control rats (P < 0.05, n = 9 for each group).
Gene_expression (expressed) of Nnat
10) Confidence 0.67 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.40 Pain Relevance 0.33
Their immunohistochemical staining revealed that Nnat was expressed on the vascular endothelium.
Gene_expression (expressed) of Nnat in vascular endothelium
11) Confidence 0.67 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.20 Pain Relevance 0.10
Their results showed that overexpression of Nnat in HAECs or in mouse carotid artery would induce increased expression of a panel of nuclear factor-kappaB (NF-?
Gene_expression (overexpression) of Nnat in carotid artery
12) Confidence 0.67 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.23 Pain Relevance 0.13
This subpopulation of primary afferent neurons demonstrated a low level of expression of Nnat in the control (Sham group) and suggests that Nnat is expressed mainly on unmyelinated C-fiber and thinly myelinated A-?
Gene_expression (expression) of Nnat in afferent neurons associated with c fibre and unmyelinated
13) Confidence 0.67 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.75 Pain Relevance 0.80
As shown in Figure 2A, the expression level of total Nnat (a molecular weight band of ~13 kDa) was progressively up-regulated at 1, 3, 5, and 7 days post-axotomy compared to the sham control rats.
Gene_expression (expression) of Nnat in band
14) Confidence 0.67 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.24 Pain Relevance 0.19
In addition, based on the Western blot results, the expression profile of total Nnat (Nnat-?
Gene_expression (expression) of Nnat
15) Confidence 0.67 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.98 Pain Relevance 0.75
This suggested that the increased expression of total Nnat was induced by peripheral nerve injury.
Gene_expression (expression) of Nnat in peripheral nerve associated with nervous system injury and peripheral nerve injury
16) Confidence 0.67 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.80 Pain Relevance 0.67
Furthermore, according to the immunohistochemical results, it showed that after the sciatic nerve was axotomized, the subcellular localization of Nnat in DRG was confirmed by peripherin-positive neuronal cells, where the expression of Nnat was also increased.
Gene_expression (expression) of Nnat in neuronal associated with dorsal root ganglion and sciatic nerve
17) Confidence 0.67 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.76 Pain Relevance 0.75
Altered neuronatin expression in the rat dorsal root ganglion after sciatic nerve transection

Background

Gene_expression (expression) of neuronatin in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and sciatic nerve
18) Confidence 0.59 Published 2010 Journal J Biomed Sci Section Title Doc Link PMC2894761 Disease Relevance 0.41 Pain Relevance 0.41
Among them, neuronatin (Nnat) was the one which expression was significantly up-regulated.
Gene_expression (expression) of neuronatin
19) Confidence 0.58 Published 2010 Journal J. Biomed. Sci. Section Abstract Doc Link 20509861 Disease Relevance 0.07 Pain Relevance 0.24
They suggested that this effect of Nnat in both db/db and high-fat diet-fed mouse aortas was mediated through phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase-dependent activation of NF-?
Gene_expression (effect) of Nnat in fat
20) Confidence 0.58 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.32 Pain Relevance 0.15

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