INT168505

Context Info Confidence 0.58 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.03 Pain Relevance 0.08

signal transduction (S100A10)

Anatomy Link Frequency thoracic 1 S100A10 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 2 78.72 lumbar region 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Exostoses 1 98.94 Synostosis 2 98.72 Congenital Anomalies 18 95.76 Gynecomastia 7 94.48 Sarcoma 4 93.56 Cancer 3 92.32 Spina Bifida 1 87.92 Malignant Neoplastic Disease 1 85.60 Pain 2 78.72 Syndrome 5 76.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cytogenetically, the lesion has also been associated with the t (7,16) (q33;p11) translocation, with the characteristic resultant FUS and CREB3L2 fusion gene.

Localization (translocation) of p11

1) Confidence 0.58 Published 2010 Journal J Foot Ankle Surg Section Abstract Doc Link 20510633 Disease Relevance 0.75 Pain Relevance 0.08

Philip et al. [9] described involvement of both the upper thoracic (T2-T5) and lower thoracic (T10-S1) vertebrae, associated with radio-ulnar synostosis, exostosis, short and broad clavicles, and a balanced t(10;20)(p11;p13) translocation.

Localization (translocation) of p11 in thoracic associated with synostosis and exostoses

2) Confidence 0.51 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712336 Disease Relevance 1.28 Pain Relevance 0

General Comments

This test has worked.