INT168537

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.11
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grik1) plasma membrane (Grik1)
Anatomy Link Frequency
neurons 6
Grik1 (Mus musculus)
Pain Link Frequency Relevance Heat
substantia gelatinosa 64 99.84 Very High Very High Very High
nociceptor 36 98.16 Very High Very High Very High
gABA 12 97.68 Very High Very High Very High
antagonist 9 96.44 Very High Very High Very High
Pain 12 90.08 High High
Spinal cord 24 87.96 High High
Action potential 5 84.44 Quite High
agonist 5 81.76 Quite High
Spinothalamic tract neurons 1 75.00 Quite High
spinal dorsal horn 5 71.60 Quite High
Disease Link Frequency Relevance Heat
Nociception 24 55.68 Quite High
Targeted Disruption 6 15.40 Low Low
Pain 14 5.00 Very Low Very Low Very Low
Ganglion Cysts 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Neuroblastoma 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results show that the GluR5 KAR subunits are expressed functionally on the SG neurons of the Vc in mice, and the expression levels of the GluR5 subunits decrease with postnatal development.
Negative_regulation (decrease) of Gene_expression (expression) of GluR5 in neurons associated with substantia gelatinosa
1) Confidence 0.57 Published 2010 Journal Brain Res. Section Abstract Doc Link 20513362 Disease Relevance 0.06 Pain Relevance 0.48
Grik1/GluR5 expression was absent from each of the TrkA, TrkB and TrkC expressing populations (Figure 4C, F, I).
Negative_regulation (absent) of Neg (absent) Gene_expression (expression) of GluR5
2) Confidence 0.38 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0.23
Grik1/GluR5 expression persisted in a sub-population of cells (37% +/- 1.3 of all neurons) in the adult (Figure 3R).


Negative_regulation (persisted) of Gene_expression (expression) of GluR5 in neurons
3) Confidence 0.38 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.05 Pain Relevance 0.18
Mechanism for GluR5 modulation of inhibitory transmission in SG neurons
Negative_regulation (transmission) of Gene_expression (modulation) of GluR5 in neurons associated with substantia gelatinosa
4) Confidence 0.37 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.55

General Comments

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