INT168766

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.54
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Pik3r1) protein complex (Pik3r1) cytoplasm (Pik3r1)
cytosol (Pik3r1) signal transduction (Pik3r1) nucleus (Pik3r1)
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 14 84.40 Quite High
cINOD 10 82.16 Quite High
Inflammation 12 26.68 Quite Low
IPN 1 10.64 Low Low
Pain 1 7.68 Low Low
COX2 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
cOX1 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 1 98.76 Very High Very High Very High
Apoptosis 10 97.80 Very High Very High Very High
Disease 7 94.60 High High
Necrosis 3 93.48 High High
Cancer 75 93.12 High High
Disorder Of Lipid Metabolism 2 92.64 High High
Atherosclerosis 11 91.92 High High
INFLAMMATION 18 75.88 Quite High
Obesity 7 62.24 Quite High
Renal Disease 1 12.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, the action of PI3K in these cases appears to be mediated, at least in part, through the regulation of STAT1 serine 727 phosphorylation [11].
Positive_regulation (mediated) of PI3K Binding (action) of
1) Confidence 0.21 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0.48 Pain Relevance 0.04
activating PI3K, Cdc42, and p21-activated kinase (PAK), which in turn
Positive_regulation (activating) of PI3K Binding (which) of
2) Confidence 0.15 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.34 Pain Relevance 0
When combined with TNFalpha, Sulindac inhibited TNFalpha-induced tRXRalpha/p85alpha interaction, leading to activation of the death receptor-mediated apoptotic pathway.
Positive_regulation (induced) of p85alpha Binding (interaction) of associated with apoptosis and death
3) Confidence 0.05 Published 2010 Journal Cancer Cell Section Abstract Doc Link 20541701 Disease Relevance 0.72 Pain Relevance 0.31

General Comments

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