INT168808

Context Info Confidence 0.02 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.13 Pain Relevance 0.08

cytoplasm (Tlr4, Ptges) isomerase activity (Ptges) signal transduction (Tlr4) nucleus (Ptges) plasma membrane (Tlr4) intracellular (Tlr4)

Tlr4 (Mus musculus) Ptges (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 3 87.36 Pain 1 46.72 COX2 2 25.00

Disease Link Frequency Relevance Heat Disease 1 63.36 INFLAMMATION 3 63.00 Pain 1 46.72 Fever 1 46.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Inhibition of Egr-1 expression reduced substantially LPS-mediated induction of COX-2 and mPGES-1 expression, resulting in a decrease in PGE(2) production.

LPS Positive_regulation (induction) of Gene_expression (expression) of mPGES-1

1) Confidence 0.02 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.13 Pain Relevance 0.08

General Comments

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