INT168964

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CAV3) Golgi apparatus (CAV3) cytoplasm (CAV3)
Anatomy Link Frequency
muscle 2
CAV3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 39 100.00 Very High Very High Very High
opioid receptor 3 93.56 High High
Enkephalin 3 91.96 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CAV-3 siRNA reduced CAV-3 protein expression, decreased CCK-8-induced contraction, and accumulated CCK-1R in the caveolae.
Negative_regulation (reduced) of Gene_expression (expression) of CAV-3 protein associated with cholecystokinin
1) Confidence 0.47 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.63
Pretreatment with cholesterol-rich liposomes inhibited the transfer of CCK-1R and of CAV-3 in the endosomes by blocking CAV-3 phosphorylation. 4-Amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (inhibitor of tyrosine kinase) reproduced these effects by blocking pCAV-3 formation, increasing CAV-3 and CCK-1R sequestration in the caveolae and impairing CCK-8-induced contraction.
Negative_regulation (inhibited) of Gene_expression (transfer) of CAV-3 associated with cholecystokinin
2) Confidence 0.30 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.57
We found that impaired muscle contraction in GBs with cholesterol stones is due to high caveolar levels of cholesterol that inhibits pCAV-3 generation.
Negative_regulation (inhibits) of Gene_expression (generation) of pCAV-3 in muscle
3) Confidence 0.30 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.48

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