INT16899

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Context Info
Confidence 0.13
First Reported 1991
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.28
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SHOX)
SHOX (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 10 100.00 Very High Very High Very High
agonist 1 99.10 Very High Very High Very High
Clonidine 1 98.30 Very High Very High Very High
Potency 2 93.72 High High
Enkephalin 2 69.00 Quite High
Disease Link Frequency Relevance Heat
Aging 5 85.08 High High
Cardiovascular Disorder Under Development 1 5.00 Very Low Very Low Very Low
Reprotox - General 2 1 5.00 Very Low Very Low Very Low
Appetite Loss 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because one of the proposed mechanisms of action of GHRP is the inhibition of somatostatin (SS), we tested the effects of propranolol, which inhibits SS, on the GH responses to GHRH and GHRP.
Negative_regulation (inhibition) of SS associated with somatostatin
1) Confidence 0.13 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1856262 Disease Relevance 0 Pain Relevance 0.26
Because one of the proposed mechanisms of action of GHRP is the inhibition of somatostatin (SS), we tested the effects of propranolol, which inhibits SS, on the GH responses to GHRH and GHRP.
Negative_regulation (inhibits) of SS associated with somatostatin
2) Confidence 0.09 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1856262 Disease Relevance 0 Pain Relevance 0.26
In old dogs, a combination of GHRH and clonidine (CLO), an alpha(2)-adrenoceptor agonist, reportedly acting via GHRH stimulation and SS inhibition, is the most effective stimulus to rejuvenate the apulsatile GH secretion.
Negative_regulation (inhibition) of SS associated with somatostatin, agonist and clonidine
3) Confidence 0.02 Published 2002 Journal Neurobiol. Aging Section Abstract Doc Link 12392795 Disease Relevance 0.28 Pain Relevance 0.32

General Comments

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