INT168991

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 12.77
Pain Relevance 9.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2rx4) transport (P2rx4) plasma membrane (P2rx4)
Anatomy Link Frequency
nerve 5
C8-B4 2
PGE2 2
P2rx4 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 105 99.98 Very High Very High Very High
Neuropathic pain 154 99.92 Very High Very High Very High
Inflammation 89 99.64 Very High Very High Very High
Stimulus evoked pain 27 99.32 Very High Very High Very High
Lasting pain 69 99.16 Very High Very High Very High
Brush evoked pain 90 98.48 Very High Very High Very High
Pain 130 98.30 Very High Very High Very High
painful pain 18 97.68 Very High Very High Very High
allodynia 70 95.88 Very High Very High Very High
antagonist 18 93.44 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 330 99.92 Very High Very High Very High
INFLAMMATION 94 99.64 Very High Very High Very High
Pain 242 99.32 Very High Very High Very High
Nervous System Injury 146 99.32 Very High Very High Very High
Hypersensitivity 46 99.12 Very High Very High Very High
Pressure And Volume Under Development 26 90.96 High High
Inflammatory Pain 33 85.44 High High
Injury 36 65.68 Quite High
Anaplastic Astrocytoma 3 22.92 Low Low
Ganglion Cysts 9 9.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Male mice lacking P2X4R (p2rx4-/-) that were backcrossed to C57BL/6J (Clea Japan) for more than 10 generations were kindly provided by Prof.
Negative_regulation (lacking) of P2X4R
1) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704200 Disease Relevance 1.46 Pain Relevance 1.07
These results indicate that P2X4R deficiency leads to a striking reduction in the tactile allodynia caused by nerve injury and, to the lesser extent, peripheral inflammation, without any defects in motor function.
Negative_regulation (deficiency) of P2X4R in nerve associated with brush evoked pain, nervous system injury and inflammation
2) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704200 Disease Relevance 1.44 Pain Relevance 0.78
Male mice lacking P2X4R (p2rx4-/-) that were backcrossed to C57BL/6J (Clea Japan) for more than 10 generations were kindly provided by Prof.
Negative_regulation (lacking) of p2rx4
3) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704200 Disease Relevance 1.46 Pain Relevance 1.07
The fact that acute physiological pain and tissue damage-induced pain were normal in p2rx4-/- mice highlights the possibility of a therapeutic benefit of blocking P2X4R in the treatment of chronic pain, especially tactile allodynia after nerve injury.


Negative_regulation (blocking) of P2X4R in nerve associated with brush evoked pain, pain, nervous system injury, lasting pain and painful pain
4) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704200 Disease Relevance 1.65 Pain Relevance 1.16
We further tested whether P2X4R deficiency also suppresses nerve injury-induced hypersensitivity to cold stimulation, a phenomenon known as cold allodynia.
Spec (whether) Negative_regulation (deficiency) of P2X4R in nerve associated with nervous system injury, allodynia and hypersensitivity
5) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704200 Disease Relevance 1.06 Pain Relevance 0.62
In conclusion, by employing a series of acute and chronic pain tests using mice lacking P2X4R, we demonstrated that the loss of P2X4R leads to a marked reduction in the degree of tactile allodynia caused by nerve injury and, to a lesser extent, in peripheral inflammation, without any defects in motor function.
Negative_regulation (loss) of P2X4R in nerve associated with brush evoked pain, nervous system injury, inflammation and lasting pain
6) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704200 Disease Relevance 1.81 Pain Relevance 1.32
In response to peripheral inflammatory challenges, mice lacking the ATP-gated P2X4 channel (P2X4R) do not develop pain hypersensitivity and show a complete absence of inflammatory PGE2 in tissue exudates.
Negative_regulation (lacking) of P2X4 in PGE2 associated with inflammation, hypersensitivity and stimulus evoked pain
7) Confidence 0.42 Published 2010 Journal EMBO J. Section Abstract Doc Link 20562826 Disease Relevance 1.20 Pain Relevance 0.92
Second, C8-B4 cells are interesting, as they offer a clean system with virtually no functional plasma membrane P2X4 receptors in the resting state and significantly elevated P2X4 receptor numbers in the activated state.
Negative_regulation (numbers) of P2X4 in C8-B4
8) Confidence 0.37 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0.07 Pain Relevance 0.13
3.5-fold increase in trafficking of P2X4 receptors to the cell surface from a lysosomal pool within ?
Negative_regulation (trafficking) of P2X4
9) Confidence 0.37 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0.05 Pain Relevance 0.05
We next exploited our findings with C8-B4 cells to investigate the mechanism by which antidepressants reduce P2X4 responses.
Spec (investigate) Negative_regulation (reduce) of P2X4 in C8-B4 associated with antidepressant
10) Confidence 0.32 Published 2010 Journal The Journal of General Physiology Section Abstract Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.22
Blockade of P2X4 signaling in microglia at 2 weeks after nerve injury can also reverse neuropathic pain [25].
Negative_regulation (Blockade) of P2X4 in nerve associated with nervous system injury and neuropathic pain
11) Confidence 0.23 Published 2007 Journal Mol Pain Section Body Doc Link PMC2186318 Disease Relevance 1.38 Pain Relevance 1.13
In response to peripheral inflammatory challenges, mice lacking the ATP-gated P2X4 channel (P2X4R) do not develop pain hypersensitivity and show a complete absence of inflammatory PGE2 in tissue exudates.
Negative_regulation (lacking) of P2X4R in PGE2 associated with inflammation, hypersensitivity and stimulus evoked pain
12) Confidence 0.08 Published 2010 Journal EMBO J. Section Abstract Doc Link 20562826 Disease Relevance 1.20 Pain Relevance 0.93

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