INT169038

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.24
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

sulfur compound metabolic process (Sult4a1) lipid metabolic process (Sult4a1) cytoplasm (Sult4a1)
Anatomy Link Frequency
neurons 1
receptor cells 1
gustatory neurons 1
Sult4a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 2 99.62 Very High Very High Very High
opioid receptor 6 99.44 Very High Very High Very High
bDMF 49 99.42 Very High Very High Very High
Nerve growth factor 6 95.84 Very High Very High Very High
nociceptor 2 90.80 High High
Spinal cord 2 71.88 Quite High
addiction 3 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 2 66.08 Quite High
Apoptosis 3 62.84 Quite High
Schizophrenia 2 59.44 Quite High
Ganglion Cysts 44 46.44 Quite Low
Death 7 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Frailty 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, [d-Ala(2),N-MePhe(4),Gly-ol(5)]enkephalin (DAMGO) treatment increased both reporter promoter activity and Sult4a1 levels in mu-opioid receptor expressing Neuro2a/mu-opioid receptor cells, and EMSAs showed this to be due to increased binding of CREB and ATF-2 to the Sult4a1 promoter.
Positive_regulation (increased) of Sult4a1 in receptor cells associated with opioid receptor and enkephalin
1) Confidence 0.63 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20571078 Disease Relevance 0.13 Pain Relevance 0.23
We also show that DAMGO treatment increases Sult4a1 mRNA and protein levels in primary mouse neurons.
Positive_regulation (increases) of Sult4a1 in neurons
2) Confidence 0.43 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20571078 Disease Relevance 0.06 Pain Relevance 0.23
Thus, it is yet to be determined whether BDNF-dependent gustatory neurons reach the NST in the absence of functional BDNF.
Positive_regulation (reach) of NST in gustatory neurons associated with bdmf
3) Confidence 0.10 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.06 Pain Relevance 0.32

General Comments

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