INT169048

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.11
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

sulfur compound metabolic process (Sult4a1) nucleus (Atf2) intracellular (Atf2)
DNA binding (Atf2) lipid metabolic process (Sult4a1) cytoplasm (Sult4a1)
Anatomy Link Frequency
receptor cells 2
Atf2 (Mus musculus)
Sult4a1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 3 99.14 Very High Very High Very High
Enkephalin 1 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 1 59.56 Quite High
Schizophrenia 1 52.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, [d-Ala(2),N-MePhe(4),Gly-ol(5)]enkephalin (DAMGO) treatment increased both reporter promoter activity and Sult4a1 levels in mu-opioid receptor expressing Neuro2a/mu-opioid receptor cells, and EMSAs showed this to be due to increased binding of CREB and ATF-2 to the Sult4a1 promoter.
Positive_regulation (increased) of ATF-2 Binding (binding) of Sult4a1 in receptor cells associated with opioid receptor and enkephalin
1) Confidence 0.38 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20571078 Disease Relevance 0.11 Pain Relevance 0.24

General Comments

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