INT169082

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.23
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MOCOS) signal transduction (GRIA1) small molecule metabolic process (MOCOS)
endoplasmic reticulum (GRIA1) plasma membrane (GRIA1) cellular_component (MOCOS)
GRIA1 (Homo sapiens)
MOCOS (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 12 98.16 Very High Very High Very High
Glutamate 29 94.64 High High
Migraine 95 90.72 High High
Glutamate receptor 14 73.04 Quite High
Central nervous system 7 67.40 Quite High
Neurotransmitter 7 66.20 Quite High
central sensitization 2 61.12 Quite High
Thalamus 2 52.52 Quite High
trigeminal ganglion 2 50.80 Quite High
headache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 12 98.16 Very High Very High Very High
Epilepsy 10 96.56 Very High Very High Very High
Headache 93 90.72 High High
Ganglion Cysts 2 50.80 Quite High
Nociception 2 49.08 Quite Low
Genetic Predisposition To Disease 2 29.84 Quite Low
Disease 10 5.00 Very Low Very Low Very Low
Migraine With Aura 6 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low
Neuroblastoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Two variants in the regulative regions of GRIA1 (rs2195450) and GRIA3 (rs3761555) genes resulted strongly associated with MA (P = 0.00002 and P = 0.0001, respectively), but not associated with MO, suggesting their role in cortical spreading depression.
GRIA1 Binding (associated) of MO
1) Confidence 0.07 Published 2010 Journal BMC Med. Genet. Section Body Doc Link 20579352 Disease Relevance 0.09 Pain Relevance 0
Two variants in the regulative regions of GRIA1 (rs2195450) and GRIA3 (rs3761555) genes resulted strongly associated with MA (P = 0.00002 and P = 0.0001, respectively), but not associated with MO, suggesting their role in cortical spreading depression.
GRIA1 Binding (associated) of MO associated with depression
2) Confidence 0.02 Published 2010 Journal BMC Med Genet Section Abstract Doc Link PMC2909201 Disease Relevance 0.43 Pain Relevance 0.51
In fact, the rs548294 SNP in GRIA1 gene was primarily associated with MO rather than MA.
GRIA1 Binding (associated) of MO
3) Confidence 0.02 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.71 Pain Relevance 0.66

General Comments

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