INT169161

Context Info Confidence 0.42 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 2.53 Pain Relevance 1.27

plasma membrane (HTR1A) signal transducer activity (HTR1A)

Anatomy Link Frequency hippocampus 4 HTR1A (Homo sapiens)

Pain Link Frequency Relevance Heat fluoxetine 7 99.78 Hippocampus 31 98.70 Serotonin 5 81.12 antidepressant 3 80.16 Glutamate 39 74.24 5HT 13 60.56 nMDA receptor 30 60.48 Glutamate receptor 3 55.76 gABA 28 54.80 Inflammation 2 50.00

Disease Link Frequency Relevance Heat Stress 82 96.80 Post-traumatic Stress Disorder 88 83.20 Anxiety Disorder 24 78.88 Cognitive Disorder 15 75.76 Neurodegenerative Disease 15 75.20 Down Syndrome 12 75.00 Intellectual Impairment 2 71.00 Frailty 6 69.20 Traumatic Stress Disorders 5 50.00 INFLAMMATION 2 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the hippocampus of untreated P15 Ts65Dn mice, we found normal 5-HT levels but a lower expression of 5-HT1A receptors and brain-derived neurotrophic factor (BDNF).

Negative_regulation (lower) of Gene_expression (expression) of 5-HT1A in hippocampus associated with hippocampus

1) Confidence 0.42 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592198 Disease Relevance 0.90 Pain Relevance 0.43

In Ts65Dn mice, fluoxetine treatment restored the expression of 5-HT1A receptors and BDNF.

Negative_regulation (restored) of Gene_expression (expression) of 5-HT1A associated with fluoxetine

2) Confidence 0.41 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592198 Disease Relevance 0.89 Pain Relevance 0.43

Repeated administration of corticosterone decreases 5-HT1A-mediated inhibition of the hippocampus (Karten et al 1999) through a process that occurs at the level of protein synthesis (Bijak et al 2001), resulting in reduced 5-HT1A receptor expression (Montgomery et al 2001).

Negative_regulation (reduced) of Gene_expression (expression) of 5-HT1A in hippocampus associated with hippocampus

3) Confidence 0.01 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.74 Pain Relevance 0.41

General Comments

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