INT169161

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.53
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1A) signal transducer activity (HTR1A)
Anatomy Link Frequency
hippocampus 4
HTR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 7 99.78 Very High Very High Very High
Hippocampus 31 98.70 Very High Very High Very High
Serotonin 5 81.12 Quite High
antidepressant 3 80.16 Quite High
Glutamate 39 74.24 Quite High
5HT 13 60.56 Quite High
nMDA receptor 30 60.48 Quite High
Glutamate receptor 3 55.76 Quite High
gABA 28 54.80 Quite High
Inflammation 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Stress 82 96.80 Very High Very High Very High
Post-traumatic Stress Disorder 88 83.20 Quite High
Anxiety Disorder 24 78.88 Quite High
Cognitive Disorder 15 75.76 Quite High
Neurodegenerative Disease 15 75.20 Quite High
Down Syndrome 12 75.00 Quite High
Intellectual Impairment 2 71.00 Quite High
Frailty 6 69.20 Quite High
Traumatic Stress Disorders 5 50.00 Quite Low
INFLAMMATION 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the hippocampus of untreated P15 Ts65Dn mice, we found normal 5-HT levels but a lower expression of 5-HT1A receptors and brain-derived neurotrophic factor (BDNF).
Negative_regulation (lower) of Gene_expression (expression) of 5-HT1A in hippocampus associated with hippocampus
1) Confidence 0.42 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592198 Disease Relevance 0.90 Pain Relevance 0.43
In Ts65Dn mice, fluoxetine treatment restored the expression of 5-HT1A receptors and BDNF.
Negative_regulation (restored) of Gene_expression (expression) of 5-HT1A associated with fluoxetine
2) Confidence 0.41 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592198 Disease Relevance 0.89 Pain Relevance 0.43
Repeated administration of corticosterone decreases 5-HT1A-mediated inhibition of the hippocampus (Karten et al 1999) through a process that occurs at the level of protein synthesis (Bijak et al 2001), resulting in reduced 5-HT1A receptor expression (Montgomery et al 2001).
Negative_regulation (reduced) of Gene_expression (expression) of 5-HT1A in hippocampus associated with hippocampus
3) Confidence 0.01 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.74 Pain Relevance 0.41

General Comments

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