INT169236

Context Info Confidence 0.36 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.37 Pain Relevance 0.36

isomerase activity (PTGES) signal transduction (PTGES) cytoplasm (PTGES)

PTGES (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 29 97.20 cytokine 3 94.64 cINOD 18 89.96 Inflammatory stimuli 2 43.20 Pain 8 5.64 Arthritis 8 5.00 Potency 6 5.00 Hyperalgesia 4 5.00 Inflammatory response 2 5.00 Acute pain 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 38 97.20 Atherosclerosis 4 32.28 Hypertension 2 31.52 Fever 6 6.04 Pain 10 5.64 Arthritis 8 5.00 Disease 8 5.00 Hyperalgesia 4 5.00 Targeted Disruption 4 5.00 Sprains And Strains 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Identification of key residues determining species differences in inhibitor binding of microsomal prostaglandin E synthase-1.

Negative_regulation (inhibitor) of microsomal prostaglandin E synthase-1 Binding (binding) of

1) Confidence 0.36 Published 2010 Journal J. Biol. Chem. Section Title Doc Link 20605783 Disease Relevance 0.37 Pain Relevance 0.36

Exchange of the same residues 115–140 in human WT MPGES1 abrogated inhibitor binding.

Negative_regulation (inhibitor) of MPGES1 Binding (binding) of

2) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2937957 Disease Relevance 0 Pain Relevance 0

We went on to locate individual residues that are important for inhibitor binding by exchanging single amino acid residues in rat MPGES1 toward the corresponding residue in the human enzyme and tested their ability to be inhibited by compound I.

Negative_regulation (inhibitor) of MPGES1 Binding (binding) of

3) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2937957 Disease Relevance 0 Pain Relevance 0

General Comments

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