INT169304

Context Info Confidence 0.23 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.18 Pain Relevance 0.57

signal transduction (PTPLA) lyase activity (PTPLA) endoplasmic reticulum (PTPLA)

PTPLA (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 2 99.96 agonist 2 99.18 Cannabinoid receptor 10 98.80 antagonist 2 74.96

Disease Link Frequency Relevance Heat Wound Healing 1 95.00 Injury 1 84.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Both the selective CB1 and TRPV1 agonists (i.e., WIN55,212-2 [WIN] and capsaicin [CAP], respectively) induced EGFR phosphorylation whereas either inhibition of its tyrosine kinase activity with AG1478 or functional blockage eliminated this response.

Phosphorylation (phosphorylation) of CAP associated with qutenza, cannabinoid receptor and agonist

1) Confidence 0.23 Published 2010 Journal Exp. Eye Res. Section Abstract Doc Link 20619260 Disease Relevance 0.18 Pain Relevance 0.57

General Comments

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