INT169318

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 4.35
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rxra) enzyme binding (Rxra) DNA binding (Rxra)
transcription factor binding (Rxra)
Anatomy Link Frequency
nucleus 2
primary neurons 1
peripheral nervous system 1
Rxra (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 73 99.68 Very High Very High Very High
Spinal cord 65 99.36 Very High Very High Very High
Peripheral nervous system 12 99.28 Very High Very High Very High
Inflammation 233 98.40 Very High Very High Very High
Endocannabinoid 9 97.36 Very High Very High Very High
depression 2 96.40 Very High Very High Very High
Cannabinoid 46 96.16 Very High Very High Very High
Central nervous system 38 92.32 High High
Dopamine 1 85.92 High High
Nucleus accumbens 5 82.96 Quite High
Disease Link Frequency Relevance Heat
Injury 56 99.68 Very High Very High Very High
INFLAMMATION 294 98.40 Very High Very High Very High
Colitis 14 98.36 Very High Very High Very High
Depression 5 96.40 Very High Very High Very High
Stress 84 96.00 Very High Very High Very High
Targeted Disruption 119 93.72 High High
Diabetes Mellitus 12 88.88 High High
Pressure And Volume Under Development 14 88.24 High High
Frailty 41 86.92 High High
Immunotherapy Of Cancer 3 86.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The RXR/PPAR heterodimer is activated by
Positive_regulation (activated) of RXR
1) Confidence 0.42 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.30 Pain Relevance 0.30
This allows ligand-dependent activation for RXR-RAR heterodimer on DR5, but not on DR1.
Positive_regulation (activation) of RXR
2) Confidence 0.36 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
Therefore, it is reasonable to regard the heterodimer as the basic functional unit of the signaling network, rather than viewing RXR and its partner monomer as separate units.
Positive_regulation (viewing) of RXR
3) Confidence 0.26 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
Second, the absence of a partner through targeted gene disruption increases the availability of RXR and cofactors.
Positive_regulation (increases) of RXR
4) Confidence 0.26 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0.34 Pain Relevance 0
Manipulation of RAR/RXR signaling in the peripheral nervous system
Positive_regulation (Manipulation) of RXR in peripheral nervous system associated with peripheral nervous system
5) Confidence 0.12 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.46 Pain Relevance 0.32
The converging point in activities of these two classes of molecules is transcriptional activation of retinoid X receptors (Rxr).
Positive_regulation (activation) of Rxr
6) Confidence 0.12 Published 2010 Journal Neuron Section Abstract Doc Link 20620876 Disease Relevance 0.32 Pain Relevance 0.38
or supported by the activation of RAR/RXR signaling.
Positive_regulation (activation) of RXR
7) Confidence 0.12 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.90 Pain Relevance 0.36
They are activated by ligand binding; form heterodimers, usually with the retinoid X receptor (RXR); translocate to the nucleus; bind to a cis-acting XRE consisting of a direct repeat of two hexanucleotides, separated by one or two nucleotides, in the promoter region of the target gene; and enhance target gene expression [17].
Positive_regulation (activated) of retinoid X receptor in nucleus
8) Confidence 0.10 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0 Pain Relevance 0
They are activated by ligand binding; form heterodimers, usually with the retinoid X receptor (RXR); translocate to the nucleus; bind to a cis-acting XRE consisting of a direct repeat of two hexanucleotides, separated by one or two nucleotides, in the promoter region of the target gene; and enhance target gene expression [17].
Positive_regulation (activated) of RXR in nucleus
9) Confidence 0.10 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0 Pain Relevance 0
This may explain some metabolic and anti-inflammatory effects but the required doses may be slightly supra-physiological and whether RXR activation occurs with physiological DHA dosing remains unclear [160].DHA can protect against oligomer-induced synaptic marker loss in primary neurons [161].
Spec (whether) Positive_regulation (activation) of RXR in primary neurons associated with inflammation
10) Confidence 0.08 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.58 Pain Relevance 0.09
Evidence of elevated JH levels was strongly supported by the temporal suppression of JHE and late induction of RXR (Figure 1), suggesting that JH levels increase in exposed D. magna over time.
Positive_regulation (induction) of RXR
11) Confidence 0.08 Published 2008 Journal Genome Biol Section Body Doc Link PMC2374704 Disease Relevance 0.16 Pain Relevance 0
It remains unknown whether JH and eicosanoids interact directly in daphnids or whether the upregulation of RXR relates to PPAR and thus eicosanoid metabolism, rather than being involved with JH.
Spec (whether) Positive_regulation (upregulation) of RXR
12) Confidence 0.08 Published 2008 Journal Genome Biol Section Body Doc Link PMC2374704 Disease Relevance 0.06 Pain Relevance 0.03
It has been shown that polyunsaturated fatty acids including arachidonic acid bind and activate RXR?
Positive_regulation (activate) of RXR
13) Confidence 0.07 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220031 Disease Relevance 0.08 Pain Relevance 0.36
Because it has been reproduced by activation of RXR with specific rexinoids, this beneficial effect has been directly attributed to the RXR/PPAR-?
Positive_regulation (activation) of RXR
14) Confidence 0.04 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.85 Pain Relevance 0.29
Although different laboratories have reported differences in the extent of activation by various NRs in NCoA6-/- MEFs, the overall conclusion is that NCoA6 functions as a coactivator for RXR, RAR, TR and PPAR.
Positive_regulation (coactivator) of RXR
15) Confidence 0.03 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.30 Pain Relevance 0
and RXR, which is further enhanced by expression of NCoA6(PRIP).
Positive_regulation (enhanced) of RXR
16) Confidence 0.03 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0

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