INT169483

From wiki-pain
Revision as of 13:46, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 6.93
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sema6a)
Anatomy Link Frequency
brain 2
Sema6a (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 4 100.00 Very High Very High Very High
tolerance 4 99.74 Very High Very High Very High
Morphine 4 99.54 Very High Very High Very High
Lasting pain 2 99.12 Very High Very High Very High
Inflammation 16 98.86 Very High Very High Very High
Neurotransmitter 13 98.64 Very High Very High Very High
Glutamate 8 98.08 Very High Very High Very High
Analgesic 3 95.52 Very High Very High Very High
Kinase C 2 88.24 High High
Central nervous system 65 81.68 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 870 100.00 Very High Very High Very High
Pain 2 99.12 Very High Very High Very High
INFLAMMATION 25 98.86 Very High Very High Very High
Cancer 141 98.18 Very High Very High Very High
Lymphatic System Cancer 5 94.00 High High
Leukemia 5 93.48 High High
Disease 85 85.96 High High
Stress 55 85.64 High High
Neurodegenerative Disease 70 83.52 Quite High
Starvation 3 82.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, we reported that some inflammatory chronic pain may inhibit morphine tolerance via kappa opioid receptor (KOR) activation.
Positive_regulation (activation) of via associated with inflammation, lasting pain, kappa opioid receptor, tolerance and morphine
1) Confidence 0.45 Published 2010 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 20663033 Disease Relevance 0.20 Pain Relevance 1.32
Hence the authors postulated that perhaps water movement via AQP8 might be important during times of rapid expansion of mitochondrial volume suchas those occurring during active oxidative phosphorylation andthose following apoptotic signals.
Positive_regulation (movement) of via associated with apoptosis
2) Confidence 0.10 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.21 Pain Relevance 0.12
In fact [54] showed that the loss in K+ ions drives AVD via AQPs, after which the AQPs are inactivated.
Positive_regulation (drives) of via
3) Confidence 0.10 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.74 Pain Relevance 0
Although AQP4 is considered to be the main water channel in the brain, surprisingly it was highly downregulated throughout lactacystin induced apoptosis suggesting that loss of water during AVD might occur via other AQPs.
Spec (might) Positive_regulation (occur) of via in brain associated with apoptosis
4) Confidence 0.10 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.60 Pain Relevance 0
It can be triggered via an intrinsic or extrinsic stimulus or via reactive oxidative species (ROS).
Positive_regulation (triggered) of via
5) Confidence 0.10 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 1.97 Pain Relevance 0.07
It can be triggered via an intrinsic or extrinsic stimulus or via reactive oxidative species (ROS).
Positive_regulation (triggered) of via
6) Confidence 0.10 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 1.89 Pain Relevance 0.07
-hydroxybutyrate is transported via SLC5A8 in a Na+-dependent manner (Fig. 1a) and that this transport is inhibited competitively by other substrates of the transporter (Fig. 1b).
Positive_regulation (transported) of via
7) Confidence 0.03 Published 2008 Journal AAPS J Section Body Doc Link PMC2751467 Disease Relevance 0 Pain Relevance 0.04
Thus, accumulation of pyruvate in cancer cells is not conducive to cell proliferation because of the ability of this metabolite to induce apoptosis via HDAC inhibition.
Positive_regulation (induce) of via associated with cancer and apoptosis
8) Confidence 0.03 Published 2008 Journal AAPS J Section Body Doc Link PMC2751467 Disease Relevance 1.17 Pain Relevance 0.03
Glutamate, the major neurotransmitter in the brain, links neuronal activation to astrocyte metabolism to enhance glucose breakdown via glycolysis, leading to generation and release of lactate from the astrocytes (24).
Positive_regulation (enhance) of via in brain associated with neurotransmitter and glutamate
9) Confidence 0.03 Published 2008 Journal AAPS J Section Body Doc Link PMC2751467 Disease Relevance 0.16 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox