INT16966

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Context Info
Confidence 0.60
First Reported 1990
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 22.50
Pain Relevance 3.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sinus 1
nasal 1
proximal 1
Nucleus 1
lung 1
CRS (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 19 97.92 Very High Very High Very High
anesthesia 13 96.88 Very High Very High Very High
ischemia 2 92.32 High High
Pain 10 91.64 High High
Angina 6 91.16 High High
cytokine 22 91.00 High High
backache 4 90.72 High High
Inflammation 132 88.40 High High
adenocard 7 87.76 High High
bradykinin 1 87.32 High High
Disease Link Frequency Relevance Heat
Cough 696 100.00 Very High Very High Very High
Chronic Sinusitis 394 100.00 Very High Very High Very High
Syndrome 72 100.00 Very High Very High Very High
Gastroesophageal Reflux Disease 48 100.00 Very High Very High Very High
Eosinophilia 25 100.00 Very High Very High Very High
Asthma 292 99.84 Very High Very High Very High
Nicotine Addiction 156 99.70 Very High Very High Very High
Myocardial Infarction 22 98.40 Very High Very High Very High
Carcinoma 16 98.32 Very High Very High Very High
Nasal Polyps 99 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most evident increase of CRS was observed during acute asthma exacerbation, in children suffering from asthma with concomitant allergic rhinitis, and in atopic asthmatics.
Positive_regulation (increase) of CRS associated with asthma, rhinitis and occupational lung diseases
1) Confidence 0.60 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20134041 Disease Relevance 1.54 Pain Relevance 0.17
We found that, in general, CRS was increased in asthmatic children compared with controls.
Positive_regulation (increased) of CRS associated with asthma
2) Confidence 0.60 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20134041 Disease Relevance 1.51 Pain Relevance 0.17
ECP was significantly increased in CRS compared to the control group (p < 0.05) and even more in CRS-NP (p < 0.02).
Positive_regulation (increased) of CRS
3) Confidence 0.43 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.48 Pain Relevance 0.12
R showed a significantly increase in CRS-NP subjects compared to CRS and in CRS compared to control subjects.
Positive_regulation (increase) of CRS
4) Confidence 0.43 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.48 Pain Relevance 0.12
It is plausible that the main role in increased CRS in children with GORD play episodes of distal acid refluxes.
Positive_regulation (increased) of CRS associated with gastroesophageal reflux disease
5) Confidence 0.40 Published 2007 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18204187 Disease Relevance 1.15 Pain Relevance 0.14
The aim of this study was to find out whether CRS in children with GORD will be changed compared with healthy children, and if so, to determine the role of proximal vs. distal reflux in these changes.
Spec (whether) Positive_regulation (changed) of CRS in proximal associated with gastroesophageal reflux disease
6) Confidence 0.40 Published 2007 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18204187 Disease Relevance 1.28 Pain Relevance 0.14
CRS in the group of children with suspected GORD [C2: 17.0 micromol/l (6.4-45.6 micromol/l)] and with confirmed GORD [C2: 13.4 micromol/l (3.6-50.9 micromol/l)] were significantly elevated (P<0.05) compared with healthy children [C2: 72.1 micromol/l (25.5-203.9 micromol/l)].
Positive_regulation (elevated) of CRS associated with cough and gastroesophageal reflux disease
7) Confidence 0.40 Published 2007 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18204187 Disease Relevance 1.72 Pain Relevance 0.19
When ventilated with the larger tidal volumes, the infants showed a highly significant increase in Crs (mean 62%, range 14-158%, P less than 0.0001).
Positive_regulation (increase) of Crs
8) Confidence 0.40 Published 1990 Journal J. Appl. Physiol. Section Abstract Doc Link 2341337 Disease Relevance 0.25 Pain Relevance 0.09
Regardless of the underlying etiology, multiple reports have correlated tobacco smoke exposure with increased prevalence of CRS and poor sinus surgery outcomes [27], [28], [46].
Positive_regulation (increased) of CRS in sinus associated with nicotine addiction and chronic sinusitis
9) Confidence 0.40 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017060 Disease Relevance 1.94 Pain Relevance 0.27
Although a common cause of CRS has not been defined, bacterial presence within the nasal and paranasal sinuses is assumed to be contributory.
Positive_regulation (cause) of CRS in nasal associated with chronic sinusitis
10) Confidence 0.40 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017060 Disease Relevance 1.12 Pain Relevance 0
EELV, Crs and PaO2 were increased at all lung conditions by the LRM (Table 1).
Positive_regulation (increased) of Crs in lung
11) Confidence 0.36 Published 2008 Journal Crit Care Section Body Doc Link PMC2374591 Disease Relevance 0 Pain Relevance 0
When tidal volume was increased and Crs remeasured, there was a significant increase in every case, with the high-volume Crs within 10% of CrsS in all but one child, in whom there was a 31.4% increase with respect to CrsS.
Positive_regulation (increase) of Crs
12) Confidence 0.31 Published 1991 Journal J. Appl. Physiol. Section Abstract Doc Link 1864777 Disease Relevance 0.33 Pain Relevance 0.75
R showed a significantly increase in CRS-NP subjects compared to CRS and in CRS compared to control subjects.
Positive_regulation (increase) of CRS
13) Confidence 0.29 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.49 Pain Relevance 0.12
All subjects Subjects in the Cortex+Nucleus group with successful, simultaneous inactivation of the cortex and nuclei immediately after each training session of Phase 1 (sessions 1–4) failed to acquire robust CRs during this Phase (see Figures 2 and 3): 3 of 4 subjects expressed no CRs during these first 4 sessions.
Neg (failed) Positive_regulation (acquire) of CRs in Nucleus
14) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912226 Disease Relevance 0 Pain Relevance 0
In the Control group, 2 of 4 subjects reached 0% CRs in the second block of training, with a group mean of 28.9±16.7% (mean ± SEM) at 10 min.
Positive_regulation (reached) of CRs
15) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912226 Disease Relevance 0 Pain Relevance 0
An imbalance in this relationship results in the CRS.
Positive_regulation (results) of CRS associated with syndrome
16) Confidence 0.19 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC2989717 Disease Relevance 0.90 Pain Relevance 0.22
We tested the hypotheses that children with recurrent cough have increased cough-receptor sensitivity (CRS) or airway hyperresponsiveness (AHR).
Positive_regulation (increased) of CRS associated with cough
17) Confidence 0.12 Published 1997 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 9196099 Disease Relevance 1.11 Pain Relevance 0.17
We conclude that AHR or increased CRS is present during the coughing phase in children with recurrent cough.
Positive_regulation (increased) of CRS associated with cough
18) Confidence 0.12 Published 1997 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 9196099 Disease Relevance 1.43 Pain Relevance 0.13
Schmidt et al. evaluated QoL after CRS and HIPEC in 67 patients with peritoneal carcinomatosis using the EORTC QLQ-C30 questionnaire.
Positive_regulation (evaluated) of CRS associated with carcinoma
19) Confidence 0.10 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2639355 Disease Relevance 0.35 Pain Relevance 0.09
This suggested that unknown nonallergic mechanism(s) contributed to both eosinophilia and higher IgE levels in CRS.


Positive_regulation (contributed) of CRS associated with chronic sinusitis and eosinophilia
20) Confidence 0.09 Published 2005 Journal Respir Res Section Body Doc Link PMC1343550 Disease Relevance 0.74 Pain Relevance 0

General Comments

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