INT169734

Context Info Confidence 0.61 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.49

nucleolus (Pno1) RNA binding (Pno1) nucleus (Pno1) biological_process (Pno1)

Anatomy Link Frequency nucleus 1 Pno1 (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 3 98.24 gABA 6 96.02 agonist 1 89.20 antagonist 1 84.96 isoflurane 1 32.00 GABAergic 1 25.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This study tested the hypothesis that GABA(A) receptors in the pontine reticular nucleus, oral part (PnO) of mouse modulate five phenotypes of arousal: sleep and wakefulness, cortical electroencephalogram (EEG) activity, acetylcholine (ACh) release in the PnO, breathing, and recovery time from general anesthesia.

Localization (release) of PnO in nucleus associated with anesthesia and gaba

1) Confidence 0.61 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20844126 Disease Relevance 0 Pain Relevance 0.49

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