INT169962

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Context Info
Confidence 0.25
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.56
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rb1, E2f4) cell cycle (Rb1, E2f4) DNA binding (Rb1, E2f4)
transcription factor binding (Rb1, E2f4) enzyme binding (Rb1) cell division (Rb1)
Rb1 (Mus musculus)
E2f4 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 2 89.08 High High
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 9 85.96 High High
Acute Erythroblastic Leukemia 2 74.72 Quite High
Hyperplasia 2 62.96 Quite High
Thrombocytopenia 1 59.88 Quite High
Leukemia 1 53.40 Quite High
Myelodysplastic Syndromes 1 52.16 Quite High
Apoptosis 6 47.08 Quite Low
Aneuploidy 1 27.76 Quite Low
Retinoblastoma 1 27.56 Quite Low
Repression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We identified a novel mechanism for SAHA in cell growth arrest through inhibition in DNA synthesis, concomitant with significant increases in the nuclear localization of pRb-2/p130 associated with E2F-4, decreases in key molecules in DNA synthesis (E2F-1, PCNA and p21), and increases in histone H3 and H4 protein and acetylation levels.
pRb Binding (associated) of E2F-4
1) Confidence 0.25 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.56 Pain Relevance 0.04

General Comments

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