INT170119

Context Info Confidence 0.01 First Reported 1999 Last Reported 1999 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.07 Pain Relevance 0

signal transduction (PECAM1, ITGAL) cell adhesion (PECAM1, ITGAL) plasma membrane (PECAM1, ITGAL) extracellular space (PECAM1)

PECAM1 (Homo sapiens) ITGAL (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 19 41.88 Inflammation 6 41.32 Angina 1 5.00 Inflammatory response 1 5.00

Disease Link Frequency Relevance Heat Adhesions 21 100.00 Multiple Organ Failure 6 80.00 Respiratory Distress 1 79.64 Critical Illness 5 50.00 INFLAMMATION 8 41.32 Agranulocytosis 2 18.64 Renal Failure 3 5.00 Sepsis 3 5.00 Disease 3 5.00 Necrosis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To our knowledge the effect of CVVHD on the important adhesion molecules CD11a, CD11b, CD18 and CD44 has not been investigated before.

adhesion Spec (investigated) Regulation (effect) of Positive_regulation (important) of CD11a associated with adhesions

1) Confidence 0.01 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 1.07 Pain Relevance 0

General Comments

This test has worked.