INT170127

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Context Info
Confidence 0.01
First Reported 1999
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.71
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ITGAL, PECAM1) cell adhesion (ITGAL, PECAM1) plasma membrane (ITGAL, PECAM1)
extracellular space (PECAM1)
Anatomy Link Frequency
leukocyte 1
ITGAL (Homo sapiens)
PECAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 6 95.16 Very High Very High Very High
cytokine 21 94.00 High High
Inflammation 17 93.60 High High
Restless leg syndrome 2 77.76 Quite High
Pain 1 66.52 Quite High
depression 7 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 22 100.00 Very High Very High Very High
Demyelinating Disease 7 95.16 Very High Very High Very High
INFLAMMATION 19 93.60 High High
Disease Progression 1 92.40 High High
Encephalitis 1 89.96 High High
Amputation 1 85.40 High High
Paralysis 1 85.20 High High
Peripheral Arterial Disease 5 83.72 Quite High
Increased Venous Pressure Under Development 8 77.76 Quite High
Respiratory Distress 1 72.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lovastatin treatment also attenuated the transmigration of mononuclear cells by downregulating the expression of leukocyte function antigen-1 (LFA-1), a ligand for intercellular adhesion molecule (ICAM), in endothelial-leukocyte interaction [88] and mononuclear cell infiltration into the CNS has been implicated in MS [89].
LFA-1 Binding (ligand) of adhesion molecule in leukocyte associated with multiple sclerosis and adhesions
1) Confidence 0.01 Published 2005 Journal J Negat Results Biomed Section Body Doc Link PMC1079931 Disease Relevance 1.62 Pain Relevance 0.61
The

CD11a-c/CD18 adhesion molecules are the most important integrins, whereas CD62L is the most important member of the selectin family.

CD11a Binding (integrins) of adhesion associated with adhesions
2) Confidence 0.01 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 1.09 Pain Relevance 0.15

General Comments

This test has worked.

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