INT170308

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2011
Negated 1
Speculated 3
Reported most in Body
Documents 159
Total Number 164
Disease Relevance 69.51
Pain Relevance 15.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ido1) oxidoreductase activity (Ido1) cytoplasm (Ido1)
Anatomy Link Frequency
P19 14
T cells 7
plasma 4
lung 4
epididymis 4
Ido1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 1102 99.68 Very High Very High Very High
Multiple sclerosis 1045 99.66 Very High Very High Very High
rheumatoid arthritis 235 99.58 Very High Very High Very High
Inflammation 1369 99.46 Very High Very High Very High
Arthritis 626 99.40 Very High Very High Very High
Serotonin 620 99.38 Very High Very High Very High
abatacept 10 98.62 Very High Very High Very High
Inflammatory mediators 212 98.52 Very High Very High Very High
Demyelination 147 97.32 Very High Very High Very High
cytokine 872 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 2790 99.92 Very High Very High Very High
Inflammatory Bowel Disease 60 99.84 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 34 99.84 Very High Very High Very High
Stress 2225 99.82 Very High Very High Very High
Mycobacterial Infection 471 99.80 Very High Very High Very High
Disease 639 99.76 Very High Very High Very High
Cancer 769 99.72 Very High Very High Very High
Demyelinating Disease 945 99.66 Very High Very High Very High
Rheumatoid Arthritis 529 99.58 Very High Very High Very High
Multiple Sclerosis 1048 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the diminished expression of MMP-1 in IDO transfectants could explain their weaker binding to this substrate.
Gene_expression (transfectants) of IDO
1) Confidence 0.75 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.12 Pain Relevance 0.03
Thus IDO overexpression resulted in an increase in PG E2 relative to the other PGs.
Gene_expression (overexpression) of IDO
2) Confidence 0.75 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.13 Pain Relevance 0.04
The phenotype produced by IDO expression could be reproduced by adding PG E2 alone to the cultures.
Gene_expression (expression) of IDO
3) Confidence 0.75 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0 Pain Relevance 0
Thus, inhibition of IDO gene expression correlated with increased expression of some but not all MMP genes in P19 cells undergoing aggregation.
Gene_expression (expression) of IDO gene in P19
4) Confidence 0.75 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0 Pain Relevance 0.07
IDO expression was observed within 12 hours of seeding into suspension with DMSO and peaked around 48-54 hours.
Gene_expression (expression) of IDO
5) Confidence 0.75 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.22 Pain Relevance 0
To examine the role of IDO expression in P19 cells, we transfected P19 cells with a DNA construct which contained a 740 bp fragment of murine IDO cDNA in the antisense orientation, under the control of the constitutively active CMV promoter in the pcDNA-3 mammalian expression vector.
Gene_expression (expression) of IDO in P19 associated with cytomegalovirus infection
6) Confidence 0.75 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.33 Pain Relevance 0
We have recently confirmed that IDO expression in RAW cells following cell passage is likewise important for correct cell adhesion (results not shown).
Gene_expression (expression) of IDO associated with adhesions
7) Confidence 0.75 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.25 Pain Relevance 0
Transfection of a full length, constitutively expressed IDO cDNA into MC57 cells in the pcDNA3 expression vector, resulted in MC57 cells developing a more rounded phenotype.
Gene_expression (expressed) of IDO cDNA
8) Confidence 0.75 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.09 Pain Relevance 0
In contrast, COX-2 protein levels were higher in clones expressing lower amounts of IDO mRNA and lower in vector only controls, whereas COX-1 protein levels were unchanged by LPS treatment.
Gene_expression (expressing) of IDO mRNA
9) Confidence 0.75 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0 Pain Relevance 0
Although, we did not determine the cell population which induced IDO1 expression in our study, it was recently shown that IDO1 protein is detectable in a number of cells and tissues such as antigen-presenting cells of epididymis, placenta, spleen, thymus, lung and digestive tract [38] which remains to be investigated in the murine stress model.
Gene_expression (expression) of IDO1 in epididymis associated with stress
10) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.45 Pain Relevance 0.09
IDO1 mRNA expression
Gene_expression (expression) of IDO1 mRNA
11) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.17 Pain Relevance 0.11
Although, we did not determine the cell population which induced IDO1 expression in our study, it was recently shown that IDO1 protein is detectable in a number of cells and tissues such as antigen-presenting cells of epididymis, placenta, spleen, thymus, lung and digestive tract [38] which remains to be investigated in the murine stress model.
Gene_expression (detectable) of IDO1 in epididymis associated with stress
12) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.46 Pain Relevance 0.09
Acute stress-induced up-regulation of IDO expression is likely linked to increased dissemination of commensal bacteria into mesenteric lymph nodes and liver which provokes a transiently increased proinflammatory cytokine bias in acutely stressed mice [37].
Gene_expression (expression) of IDO in liver associated with stress and cytokine
13) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.48 Pain Relevance 0.13
blockade prevented the up-regulation of IDO1 expression in acutely stressed mice.
Gene_expression (expression) of IDO1
14) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.51 Pain Relevance 0.14
caused time-dependent induction of IDO gene expression and activity in cultured normal fibroblasts [4].
Gene_expression (expression) of IDO gene in fibroblasts
15) Confidence 0.72 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 0.62 Pain Relevance 0.15
Expression of the IDO gene is induced in most cell types in response to infection with microbial agents via activation of toll-like receptors.
Gene_expression (Expression) of IDO gene associated with infection
16) Confidence 0.72 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 0.83 Pain Relevance 0.18
Therefore, we treated IDO transfected RAW cells and controls with LPS and measured COX-2 expression 24 hours later.
Gene_expression (transfected) of IDO
17) Confidence 0.66 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0 Pain Relevance 0
Clone C2, which expressed low levels of IDO antisense, depleted similar levels of tryptophan to the sense control.
Gene_expression (expressed) of IDO
18) Confidence 0.66 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.12 Pain Relevance 0
We transfected the murine macrophage cell line RAW 264.7 with a construct in which IDO was expressed under the control of the murine MHC Class II promoter (Fig 1A).
Gene_expression (expressed) of IDO in RAW 264
19) Confidence 0.66 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.38 Pain Relevance 0.08
To determine if IDO expression was restricted to cell interactions with standard tissue culture substrates and to further explore the possibility that IDO altered inter-cellular adhesiveness, we studied the murine embryonic carcinoma cell line P19.
Spec (determine) Gene_expression (expression) of IDO in P19 associated with carcinoma
20) Confidence 0.66 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.30 Pain Relevance 0

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