INT170324

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Context Info
Confidence 0.13
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 6.28
Pain Relevance 2.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp1a) extracellular region (Mmp1a) proteinaceous extracellular matrix (Mmp1a)
Anatomy Link Frequency
chondrocytes 4
fibroblasts 4
stromal cells 2
Mmp1a (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 200 100.00 Very High Very High Very High
rheumatoid arthritis 210 99.10 Very High Very High Very High
Arthritis 157 86.80 High High
antagonist 30 82.96 Quite High
cytokine 72 79.80 Quite High
Inflammation 111 79.44 Quite High
Kinase C 3 66.64 Quite High
Osteoarthritis 47 56.52 Quite High
Inflammatory mediators 5 36.16 Quite Low
Dismenorea 3 32.68 Quite Low
Disease Link Frequency Relevance Heat
Premature Birth 120 99.32 Very High Very High Very High
Rheumatoid Arthritis 216 99.10 Very High Very High Very High
Osteoarthritis 53 99.00 Very High Very High Very High
Severe Combined Immunodeficiency 8 97.52 Very High Very High Very High
Osteogenic Sarcomas 3 92.56 High High
Adhesions 60 90.24 High High
Breast Cancer 25 89.28 High High
Arthritis 168 86.80 High High
Malignant Neoplastic Disease 4 85.60 High High
Pre-term Labor 39 80.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RAW transfectants over-expressing IDO showed reduced expression of collagenase I (MMP-1), and also bound less well to collagen-coated plates than controls.
Negative_regulation (reduced) of Gene_expression (expression) of MMP-1
1) Confidence 0.13 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.15 Pain Relevance 0.04
Thus, the diminished expression of MMP-1 in IDO transfectants could explain their weaker binding to this substrate.
Negative_regulation (diminished) of Gene_expression (expression) of MMP-1
2) Confidence 0.13 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.13 Pain Relevance 0.03
Similarly, Manacu et al. [72] found that, in primary cultures of human osteoarthritic chondrocytes, the presence of ET-1 in the medium triggered increased production of MMP-1 and MMP-13.
Negative_regulation (triggered) of Gene_expression (production) of MMP-1 in chondrocytes associated with osteoarthritis
3) Confidence 0.10 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.66 Pain Relevance 0.17
Furthermore, those mice in which ECE-1 and, consequently, MMP-1 levels were reduced were largely prevented from developing preterm delivery (manuscript submitted).
Negative_regulation (reduced) of Gene_expression (levels) of MMP-1 associated with premature birth
4) Confidence 0.10 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.76 Pain Relevance 0.16
Furthermore, those mice in which ECE-1 and, consequently, MMP-1 levels were reduced were largely prevented from developing preterm delivery (manuscript submitted).
Negative_regulation (prevented) of Gene_expression (levels) of MMP-1 associated with premature birth
5) Confidence 0.10 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.76 Pain Relevance 0.16
resulted in a significant reduction in detectable MMP-1 and MMP-3 levels when compared to that elicited by the IL-1?
Negative_regulation (reduction) of Gene_expression (levels) of MMP-1 associated with metalloproteinase
6) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888198 Disease Relevance 0.52 Pain Relevance 0.90
Derenne et al. showed that the bisphosphonates pamidronate and zoledronate inhibited interleukin-6-induced production of matrix metalloproteinase-1 by bone marrow stromal cells [13].
Negative_regulation (inhibited) of Gene_expression (production) of matrix metalloproteinase-1 in stromal cells associated with metalloproteinase
7) Confidence 0.04 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138714 Disease Relevance 0.71 Pain Relevance 0.05
In addition, the level of tissue inhibitor of MMP-1 (TIMP-1), a natural protein inhibitor produced by chondrocytes, also remained stable (data not shown).
Negative_regulation (inhibitor) of Gene_expression (produced) of MMP-1 in chondrocytes associated with metalloproteinase
8) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.32 Pain Relevance 0.24
Ribozymes and an antisense construct targeting the destruction of MMP-1 delivered to RA synovial fibroblasts via retroviral vectors decreased MMP-1 production and reduced the invasiveness of RA synovial fibroblasts in a SCID mouse model of RA, suggesting that this may be an effective approach to inhibiting cartilage destruction in RA [119, 120].
Negative_regulation (decreased) of Gene_expression (production) of MMP-1 in fibroblasts associated with severe combined immunodeficiency and rheumatoid arthritis
9) Confidence 0.03 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 1.47 Pain Relevance 0.79
B1 markedly suppressed the generation of fibroblast-like cells as well as the production of MMP-1 and VEGF under the influence of TNF-?
Negative_regulation (suppressed) of Gene_expression (production) of MMP-1 in fibroblast associated with metalloproteinase
10) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.79 Pain Relevance 0.39

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