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Context Info
Confidence 0.61
First Reported 1980
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 55
Total Number 55
Disease Relevance 34.88
Pain Relevance 14.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TFPI) extracellular region (TFPI) plasma membrane (TFPI)
Anatomy Link Frequency
EPI 17
plasma 6
CSF 2
peritoneal fluid 2
blood 2
TFPI (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 35 99.80 Very High Very High Very High
tolerance 48 99.68 Very High Very High Very High
antagonist 66 98.92 Very High Very High Very High
endometriosis 336 98.72 Very High Very High Very High
anesthesia 27 98.68 Very High Very High Very High
Angina 55 98.36 Very High Very High Very High
Clonidine 8 97.88 Very High Very High Very High
aspirin 92 97.60 Very High Very High Very High
agonist 166 97.48 Very High Very High Very High
spinal inflammation 4 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 155 100.00 Very High Very High Very High
Immunization 61 100.00 Very High Very High Very High
Cytomegalovirus Infection 19 100.00 Very High Very High Very High
Pressure And Volume Under Development 10 100.00 Very High Very High Very High
Myocardial Infarction 57 99.98 Very High Very High Very High
Hypercholesterolemia 2 99.92 Very High Very High Very High
Systemic Sclerosis 107 99.84 Very High Very High Very High
Sickle Cell Anemia 6 99.84 Very High Very High Very High
Toxocariasis 12 99.80 Very High Very High Very High
Herpes Zoster 28 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Systolic blood pressure increased in the Epi group, and diastolic blood pressure increased in both groups.
Positive_regulation (increased) of Epi in blood
1) Confidence 0.61 Published 2010 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 20031290 Disease Relevance 0 Pain Relevance 0
We conclude that high physiological concentrations of Epi can enhance Ra in exercising humans, but normally Epi is not a major stimulus.
Positive_regulation (concentrations) of Epi associated with rheumatoid arthritis
2) Confidence 0.50 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8368297 Disease Relevance 0.78 Pain Relevance 0.13
Plasma TF pathway inhibitor (TFPI) antigen levels were normal in SCD patients, suggesting that accelerated clearance of FVIIa by the TFPI pathway was not responsible for the reduced FVIIa levels.
Positive_regulation (normal) of TFPI in Plasma associated with sickle cell anemia
3) Confidence 0.49 Published 1998 Journal Blood Section Abstract Doc Link 9596669 Disease Relevance 0.84 Pain Relevance 0.09
Serial changes in angiotensin II, epi- and norepinephrine as well as thromboxane B2 (the stable derivate of thromboxane A2), and malondialdehyde were determined at baseline (I), immediately after 5 minutes cold water hand immersion (II), and following 10 minutes recovery (III).
Positive_regulation (changes) of epi
4) Confidence 0.49 Published 1989 Journal Int. J. Cardiol. Section Abstract Doc Link 2807608 Disease Relevance 0.36 Pain Relevance 0.10
CONCLUSIONS: We have demonstrated that not only the plasma TF levels but also the plasma-free TFPI levels are elevated in patients with unstable angina.
Positive_regulation (elevated) of TFPI in plasma
5) Confidence 0.46 Published 1999 Journal Circulation Section Body Doc Link 10359735 Disease Relevance 0 Pain Relevance 0
As to the degree of hypotensive activity, NIF epi was followed by VER, NTG 0.1, NIF ip. and NTG 0.15.
Positive_regulation (followed) of epi associated with hypotension
6) Confidence 0.45 Published 1998 Journal Life Sci. Section Abstract Doc Link 9851315 Disease Relevance 0.34 Pain Relevance 0.38
CONCLUSIONS: Training with EPI-NO increases significantly the likelihood of having an intact perineum and reduces the episiotomy rate.


Positive_regulation (increases) of EPI-NO in EPI
7) Confidence 0.42 Published 2009 Journal Aust N Z J Obstet Gynaecol Section Body Doc Link 19780729 Disease Relevance 0.07 Pain Relevance 0
Electrical stimulation of the DM and VLM produced increases in blood pressure and in plasma NE and EPI levels that were enhanced after acute vagotomies.
Positive_regulation (enhanced) of EPI in EPI associated with medulla and pressure and volume under development
8) Confidence 0.40 Published 1991 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 1869769 Disease Relevance 0.47 Pain Relevance 0.81
Electrical stimulation of the DM and VLM produced increases in blood pressure and in plasma NE and EPI levels that were enhanced after acute vagotomies.
Positive_regulation (increases) of EPI in EPI associated with medulla and pressure and volume under development
9) Confidence 0.40 Published 1991 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 1869769 Disease Relevance 0.42 Pain Relevance 0.76
PaCO2 significantly increased postoperatively in group C and EPI.
Positive_regulation (increased) of EPI in EPI
10) Confidence 0.40 Published 1994 Journal Masui Section Abstract Doc Link 8309062 Disease Relevance 0.58 Pain Relevance 0.98
The EPI group experienced a 30-fold increase in plasma EPI levels by 2 min after injection; these concentrations were physiologically active, as evidenced by increased pulse rate and systolic blood pressure.
Positive_regulation (increase) of EPI in EPI associated with heart rate under development
11) Confidence 0.40 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2527244 Disease Relevance 0.26 Pain Relevance 0.09
The present study evaluated the hypothesis that increased plasma levels of epinephrine (EPI) stimulate immunoreactive beta-endorphin (i beta END) secretion in humans experiencing a mild stress.
Positive_regulation (increased) of EPI in plasma associated with stress
12) Confidence 0.40 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2527244 Disease Relevance 0.23 Pain Relevance 0.09
Thus, exploiting visits for curative care would have been a cost-effective way of fully immunizing a child and increasing the EPI coverage.
Positive_regulation (increasing) of EPI in EPI associated with immunization
13) Confidence 0.37 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2405792 Disease Relevance 0.66 Pain Relevance 0.08
Increased TFPI inhibit the extrinsic coagulation system, but the procoagulant system may be activated concurrently.
Positive_regulation (Increased) of TFPI
14) Confidence 0.36 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.51 Pain Relevance 0.36
Plasma vWF, TFPI and s-TM levels were significantly increased compared with controls only in patients exhibiting vascular complications.
Positive_regulation (increased) of TFPI in Plasma
15) Confidence 0.36 Published 2008 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2663449 Disease Relevance 1.03 Pain Relevance 0.04
Increased circulating levels of vWF, PAI-1, t-PA, TFPI, and s-TM have been reported in patients with NIDDM (Collier et al 1992; McGill et al 1994; Bagg et al 2001; Aso et al 2002; Leurs et al 2002; Rigla et al 2006).
Positive_regulation (Increased) of TFPI associated with diabetes mellitus
16) Confidence 0.36 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 1.21 Pain Relevance 0.04
Tissue factor pathway inhibitor TFPI activity and thrombomodulin levels were increased in all elderly subjects, with positive association between HbA (1c), TFPI activity and vWF antigen.
Positive_regulation (increased) of Tissue factor pathway
17) Confidence 0.27 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.29 Pain Relevance 0.21
Tissue factor pathway inhibitor TFPI activity and thrombomodulin levels were increased in all elderly subjects, with positive association between HbA (1c), TFPI activity and vWF antigen.
Positive_regulation (increased) of TFPI
18) Confidence 0.27 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.22 Pain Relevance 0.21
This propranolol concentration (30 nM) is sufficient to prevent EPI activation of ?
Positive_regulation (activation) of EPI in EPI
19) Confidence 0.26 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0
In eight patients undergoing similar operations during low spinal anesthesia, no inhibition of the AIR to glucose occurred, and plasma NE and Epi did not increase significantly during or after the operation.
Neg (not) Positive_regulation (increase) of Epi in plasma associated with anesthesia and hyperinsulinism
20) Confidence 0.26 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6999007 Disease Relevance 0.80 Pain Relevance 0.59

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