INT170723

Context Info Confidence 0.24 First Reported 2001 Last Reported 2001 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0

cytoplasm (Calm2, Siah1a) cytosol (Calm2, Siah1a) cell cycle (Calm2, Siah1a) cell differentiation (Siah1a) nucleoplasm (Calm2) ligase activity (Siah1a)

Calm2 (Rattus norvegicus) Siah1a (Rattus norvegicus)

Pain Link Frequency Relevance Heat Glutamate receptor 8 50.00 Glutamate 24 41.76 imagery 4 5.00 addiction 2 5.00 tetrodotoxin 2 5.00 Neuronal excitability 2 5.00

Disease Link Frequency Relevance Heat Ganglion Cysts 12 5.00 Cancer 2 5.00 Apoptosis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

By analogy to group III mGluRs, the ability of Siah1a to compete with CaM for binding to group I mGluRs was considered a potential mechanism for the actions of Siah1a on group I mGluR-mediated calcium current inhibition.

CaM Binding (compete) of Siah1a

1) Confidence 0.24 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0

Alternatively, the presence of Siah1a itself may occlude G protein coupling, with the CaM interaction being incidental.

CaM Binding (interaction) of Siah1a

2) Confidence 0.24 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.