INT170743

Context Info Confidence 0.38 First Reported 2001 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.57 Pain Relevance 0

oxidoreductase activity (Scd1) endoplasmic reticulum (Scd1) lipid metabolic process (Scd1)

Anatomy Link Frequency liver 2 Scd1 (Mus musculus)

Pain Link Frequency Relevance Heat ischemia 3 5.00 chemokine 1 5.00 Pain score 1 5.00 adenocard 1 5.00 qutenza 1 5.00 Bioavailability 1 5.00

Disease Link Frequency Relevance Heat Sickle Cell Anemia 46 100.00 Acute Chest Syndrome 35 98.60 Fatty Liver 1 98.00 Targeted Disruption 5 96.04 Disease 4 91.28 Obesity 7 89.40 Adhesions 12 79.84 Hemoglobinopathy 1 74.56 Hyperhomocysteinemia 2 36.92 Increased Venous Pressure Under Development 1 28.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In a more mechanistic fashion, recent studies have also suggested EGCG may alter food digestibility [15,36] and downregulate stearoyl-CoA desaturase (SCD1) gene expression [15], which may reduce adiposity, decrease lipid synthesis and increase liver fatty acid oxidation, as was found in SCD1 knockout mice [15,37].

Negative_regulation (reduce) of Gene_expression (expression) of SCD1 in liver associated with targeted disruption and fatty liver

1) Confidence 0.38 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2276475 Disease Relevance 0.35 Pain Relevance 0

Further work is necessary to define more clearly the oxidant/antioxidant profile of SCD patients at baseline and during VOCs, including ACS, and to examine the clinical effect of pharmacologic intervention to reduce oxidant production in SCD.

Negative_regulation (reduce) of Gene_expression (production) of SCD associated with sickle cell anemia and acute chest syndrome

2) Confidence 0.10 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 1.22 Pain Relevance 0

General Comments

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