INT170939

Context Info Confidence 0.65 First Reported 2001 Last Reported 2007 Negated 2 Speculated 0 Reported most in Body Documents 14 Total Number 19 Disease Relevance 4.59 Pain Relevance 0.98

molecular_function (Lpo) cellular_component (Lpo) biological_process (Lpo)

Anatomy Link Frequency striatum 1 Lpo (Mus musculus)

Pain Link Frequency Relevance Heat midbrain 90 99.12 Nicotine 13 63.24 Dopamine 24 5.00 Substantia nigra 24 5.00 anesthesia 19 5.00

Disease Link Frequency Relevance Heat Stress 218 99.68 Urological Neuroanatomy 42 97.84 Nicotine Addiction 65 97.64 Genetic Predisposition To Disease 13 75.64 Disease 71 73.64 Parkinson's Disease 24 69.64 Cancer 26 50.28 Sprains And Strains 18 39.36 Increased Venous Pressure Under Development 13 9.16 Pulmonary Disease 13 8.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, the rate of increase of LPO in case of AT + smoked animals were comparatively less.

Positive_regulation (increase) of LPO

1) Confidence 0.65 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.29 Pain Relevance 0

However, AT appears to be responsible for the retarded increase of LPO in the AT + smoked group with increase in the duration of smoking.

Positive_regulation (increase) of LPO associated with nicotine addiction

2) Confidence 0.65 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.30 Pain Relevance 0

As the exposure of CS to the mice was extended from 2 to 4, 6 and 8 weeks, a significant increase in the LPO levels was observed.

Positive_regulation (increase) of LPO

3) Confidence 0.65 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.39 Pain Relevance 0

The level of LPO after a single ip dose (10 mg/kg) was increased in as short a time as 1 hr (although not significantly) and persisted for up to 28 days.

Positive_regulation (increased) of LPO

4) Confidence 0.61 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2022643 Disease Relevance 0.06 Pain Relevance 0.12

Multiple doses of PQ significantly increased the level of LPO in each region (region ANOVAs: VM, F3,12 = 9.9, p = 0.001; STR, F3,12 =17.9, p < 0.0001; FCtx, F3,12 = 3.8, p = 0.04) when measured after 1 week compared with saline.

Positive_regulation (increased) of LPO associated with urological neuroanatomy and midbrain

5) Confidence 0.61 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2022643 Disease Relevance 0.19 Pain Relevance 0.15

However, the extent of the increase in the pulmonary LPO levels in the AT + smoked group was comparatively low as compared to the animals not fed with AT and only exposed to CS.

Positive_regulation (increase) of LPO

6) Confidence 0.57 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.38 Pain Relevance 0

Therefore, the depletion of GSH seems to be associated with the increase of LPO.

Positive_regulation (increase) of LPO

7) Confidence 0.57 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.21 Pain Relevance 0

It seems that the treatment of CS inhalation for 2 weeks was not enough to pose any significant oxidative stress and thereby no increase in LPO.

Neg (no) Positive_regulation (increase) of LPO associated with stress

8) Confidence 0.57 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.54 Pain Relevance 0.03

Interestingly, repeated dosing did not result in an increase in the amount of LPO (Figure 4B).

Positive_regulation (increase) of LPO

9) Confidence 0.53 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2022643 Disease Relevance 0.18 Pain Relevance 0.16

Younes and Siegers [11] have also observed that depletion of GSH enhances LPO.

Positive_regulation (enhances) of LPO

10) Confidence 0.47 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.27 Pain Relevance 0

However, the extent of increase in LPO levels due to CS exposure for 4, 6 or 8 weeks in the mice treated with AT was comparatively less.

Positive_regulation (increase) of LPO

11) Confidence 0.44 Published 2001 Journal BMC Biochem Section Abstract Doc Link PMC60661 Disease Relevance 0.12 Pain Relevance 0

It was also observed that as the exposure to CS was extended from 4 to 6 and then to 8 weeks, there was a corresponding increase in the pulmonary LPO levels in both, the smoked as well as the AT + smoked group.

Positive_regulation (increase) of LPO

12) Confidence 0.44 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.28 Pain Relevance 0

In our studies, a significant decrease in the GSH levels was observed in both the smoked as well as AT + smoked groups and concomitantly there was an increase in the LPO levels.

Positive_regulation (increase) of LPO

13) Confidence 0.44 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.21 Pain Relevance 0

There was a gradual increase in the LPO levels as the extent of CS inhalation increased from 4 to 8 weeks.

Positive_regulation (increase) of LPO

14) Confidence 0.44 Published 2001 Journal BMC Biochem Section Abstract Doc Link PMC60661 Disease Relevance 0.12 Pain Relevance 0

However, the extent of increase in LPO levels was comparatively less in the AT + smoked group.

Positive_regulation (increase) of LPO

15) Confidence 0.41 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.06 Pain Relevance 0

Despite the cumulative tissue levels of PQ after one, three, and five doses, the level of LPO was not further increased.

Neg (not) Positive_regulation (increased) of LPO

16) Confidence 0.41 Published 2007 Journal Environ Health Perspect Section Abstract Doc Link PMC2022643 Disease Relevance 0.24 Pain Relevance 0.17

An elevated level of LPO was still present in VM after 28 days.

Positive_regulation (elevated) of LPO associated with midbrain

17) Confidence 0.41 Published 2007 Journal Environ Health Perspect Section Abstract Doc Link PMC2022643 Disease Relevance 0.26 Pain Relevance 0.18

In this phase of study it was observed that CS inhalation triggered LPO both in smoked and AT + smoked group.

Positive_regulation (triggered) of LPO

18) Confidence 0.38 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.21 Pain Relevance 0

The level of tissue lipid peroxides (LPO) was differentially elevated in three regions, being highest in VM, lower in striatum (STR), and least in frontal cortex (FCtx), with the earliest significant elevation detected at 1 day.

Positive_regulation (elevated) of LPO in striatum associated with urological neuroanatomy and midbrain

19) Confidence 0.35 Published 2007 Journal Environ Health Perspect Section Abstract Doc Link PMC2022643 Disease Relevance 0.26 Pain Relevance 0.18

General Comments

This test has worked.