INT171029

Context Info Confidence 0.14 First Reported 2002 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.87 Pain Relevance 1.48

cytosol (JUN) nucleoplasm (JUN) nuclear chromosome (JUN) aging (JUN) nucleus (JUN) DNA binding (JUN)

Anatomy Link Frequency nucleus 2 JUN (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 140 96.32 cytokine 52 96.28 Nicotine 192 94.24 bradykinin 84 89.84 chemokine 31 83.04 corticosteroid 1 67.28 depression 2 65.68 antagonist 21 55.52 cINOD 3 50.08 agonist 25 50.00

Disease Link Frequency Relevance Heat Apoptosis 141 98.84 Necrosis 7 97.52 Cancer 12 97.16 Dna Damage 1 97.12 INFLAMMATION 160 96.32 Asthma 71 96.32 Pulmonary Disease 8 80.12 Adhesions 11 74.88 Disease 9 66.96 Depression 2 65.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Upon activation, JNKs translocate to the nucleus to phosphorylate and enhance the transcriptional activity of JUN [7].

Positive_regulation (enhance) of Transcription (activity) of JUN in nucleus

1) Confidence 0.14 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.78 Pain Relevance 0.10

Activation of ERK5 and the subsequent transcription of c-JUN, but not ERK1/2, can be blocked by cAMP through cAMP-dependent protein kinase (PKA) [17].

Positive_regulation (Activation) of Transcription (transcription) of c-JUN

2) Confidence 0.07 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.73 Pain Relevance 0.20

Activation of ERK5 and the subsequent transcription of c-JUN, but not ERK1/2, can be blocked by cAMP through PKA [17].

Positive_regulation (Activation) of Transcription (transcription) of c-JUN

3) Confidence 0.07 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.12 Pain Relevance 0.43

Mechanistically, it has been proposed that glucocorticoid receptors interact with transcription factors such as activator protein-1 and nuclear factor-?

Positive_regulation (as) of Transcription (transcription) of activator protein-1

4) Confidence 0.05 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.25 Pain Relevance 0.75

General Comments

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