INT1711

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2007
Negated 2
Speculated 0
Reported most in Abstract
Documents 54
Total Number 54
Disease Relevance 6.55
Pain Relevance 32.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
striatum 6
brain 4
PGE2 4
hypothalamus 4
neurons 4
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 255 100.00 Very High Very High Very High
Dopamine 34 100.00 Very High Very High Very High
Dynorphin 20 100.00 Very High Very High Very High
medulla 10 100.00 Very High Very High Very High
opioid receptor 10 100.00 Very High Very High Very High
cocaine 6 100.00 Very High Very High Very High
withdrawal 2 100.00 Very High Very High Very High
antagonist 23 99.98 Very High Very High Very High
narcan 19 99.96 Very High Very High Very High
Nicotine 8 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 16 100.00 Very High Very High Very High
Bordatella Infection 14 99.86 Very High Very High Very High
Aging 1 99.84 Very High Very High Very High
Status Epilepticus 4 98.92 Very High Very High Very High
Convulsion 15 98.46 Very High Very High Very High
Pain 4 98.40 Very High Very High Very High
Generalized Anxiety Disorder 4 97.88 Very High Very High Very High
Poisoning 5 97.44 Very High Very High Very High
Epilepsy 6 97.40 Very High Very High Very High
Urological Neuroanatomy 5 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apomorphine, but not naloxone, prevented elevation of enkephalin levels after a one month FLU administration.
Negative_regulation (prevented) of Positive_regulation (elevation) of enkephalin associated with narcan and enkephalin
1) Confidence 0.59 Published 1984 Journal Neuropeptides Section Abstract Doc Link 6514149 Disease Relevance 0 Pain Relevance 0.61
Adrenal neuropeptide Y mRNA but not preproenkephalin mRNA induction by stress is impaired by aging in Fischer 344 rats.
Negative_regulation (impaired) of Neg (not) Positive_regulation (induction) of preproenkephalin associated with stress, aging, neuropeptide and enkephalin
2) Confidence 0.58 Published 1998 Journal Mech. Ageing Dev. Section Title Doc Link 9622227 Disease Relevance 0.78 Pain Relevance 0.30
Estradiol-induced enkephalin levels were greatly reduced in antisense-treated groups.
Negative_regulation (reduced) of Positive_regulation (induced) of enkephalin associated with enkephalin
3) Confidence 0.57 Published 1997 Journal Brain Res. Section Abstract Doc Link 9449413 Disease Relevance 0.31 Pain Relevance 0.48
The elevations of both proENK and proDYN mRNA levels induced by KA were inhibited by pre-administration with phenidone, but not with esculetin and aspirin.
Negative_regulation (inhibited) of Positive_regulation (elevations) of proENK associated with aspirin
4) Confidence 0.57 Published 1998 Journal Brain Res. Section Abstract Doc Link 9519284 Disease Relevance 0.26 Pain Relevance 0.37
Adding naloxone (1 mg/kg) to the treatment regimen enhanced the blockade of epinephrine excretion and largely prevented the antibody-induced increase in Met-EnK-IR.
Negative_regulation (prevented) of Positive_regulation (increase) of EnK associated with narcan
5) Confidence 0.57 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7861161 Disease Relevance 0 Pain Relevance 0.48
The increased proENK mRNA level in forskolin-treated cells was slightly decreased 24 h after the stimulation, whereas the level of proENK mRNA returned to basal levels in PMA-treated cells.
Negative_regulation (decreased) of Positive_regulation (increased) of proENK mRNA
6) Confidence 0.56 Published 1996 Journal Neuropeptides Section Abstract Doc Link 8923515 Disease Relevance 0 Pain Relevance 0.30
Lactation inhibits stress-mediated secretion of corticosterone and oxytocin and hypothalamic accumulation of corticotropin-releasing factor and enkephalin messenger ribonucleic acids.
Negative_regulation (inhibits) of Positive_regulation (accumulation) of enkephalin associated with stress and enkephalin
7) Confidence 0.56 Published 1989 Journal Endocrinology Section Title Doc Link 2785027 Disease Relevance 0.36 Pain Relevance 0.43
The grafted nigral neurons reversed the lesion-induced up-regulation of preproenkephalin messenger RNA in the whole striatal complex.
Negative_regulation (reversed) of Positive_regulation (regulation) of preproenkephalin messenger RNA in neurons
8) Confidence 0.55 Published 1993 Journal Neuroscience Section Abstract Doc Link 8115038 Disease Relevance 0.08 Pain Relevance 0.28
The elevations of both proENK and proDYN mRNA levels induced by KA were inhibited by pre-administration of CHX (15 mg/kg i.p.).
Negative_regulation (inhibited) of Positive_regulation (induced) of proENK
9) Confidence 0.55 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.08
Finally, luzindole (melatonin receptor antagonist) administration, was not able to prevent the enkephalin tissue increase, induced with the MEL administration (150microg/kg).
Negative_regulation (prevent) of Positive_regulation (increase) of enkephalin associated with antagonist and enkephalin
10) Confidence 0.55 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17988732 Disease Relevance 0 Pain Relevance 0.45
The blockade of KA-induced proENK and proDYN mRNA levels by the pre-treatment with L-ARG was well correlated with proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, JunD, JunB, and c-Jun, as well as AP-1 and ENKCRE-2 DNA binding activities.
Negative_regulation (blockade) of Positive_regulation (induced) of proENK
11) Confidence 0.53 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.08
Systemic administration of both quinpirole and scopolamine blocked the elevation of striatal enkephalin messenger RNA normally observed in 6-hydroxydopamine-lesioned rats.
Negative_regulation (blocked) of Positive_regulation (elevation) of enkephalin associated with enkephalin
12) Confidence 0.51 Published 1994 Journal Neuroscience Section Abstract Doc Link 7534387 Disease Relevance 0 Pain Relevance 0.91
Thyroid hormone coadministration inhibits the estrogen-stimulated elevation of preproenkephalin mRNA in female rat hypothalamic neurons.
Negative_regulation (inhibits) of Positive_regulation (elevation) of preproenkephalin in neurons associated with enkephalin
13) Confidence 0.49 Published 1999 Journal Neuroendocrinology Section Title Doc Link 10516479 Disease Relevance 0.09 Pain Relevance 0.23
A dose- and time-dependent increase of striatal ENK level was observed after chronic administration of the neuroleptics (NL), but 8 days after withdrawal of chronically administered NL striatal ENK was decreased.
Negative_regulation (decreased) of Positive_regulation (increase) of ENK associated with enkephalin and withdrawal
14) Confidence 0.43 Published 1991 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 1881995 Disease Relevance 0 Pain Relevance 0.85
A topical application of dibucaine abolished the formalin-induced increase in the release of immunoreactive Met-enkephalin.
Negative_regulation (abolished) of Positive_regulation (increase) of Met-enkephalin associated with enkephalin
15) Confidence 0.43 Published 1984 Journal Brain Res. Bull. Section Abstract Doc Link 6713210 Disease Relevance 0 Pain Relevance 0.50
In contrast, a significant increase in enkephalin messenger RNA was not detected until striatal dopamine was reduced to 10% of control levels.
Negative_regulation (reduced) of Positive_regulation (increase) of enkephalin associated with dopamine and enkephalin
16) Confidence 0.43 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8738153 Disease Relevance 0 Pain Relevance 1.19
The same treatment produced, in adrenal medulla, a shift from higher molecular weight to lower molecular weight enkephalin-containing peptides, an increase of enkephalin peptides, and a decrease of proenkephalin mRNA content.
Negative_regulation (produced) of Positive_regulation (increase) of enkephalin in adrenal medulla associated with medulla and enkephalin
17) Confidence 0.43 Published 1985 Journal J. Neurosci. Section Abstract Doc Link 4078631 Disease Relevance 0 Pain Relevance 1.20
This regimen of nicotine also decreased levels of native Met-enkephalin and of both native and cryptic Leu-enkephalin in neurointermediate lobe, consistent with nicotine-induced release of both proenkephalin A- and prodynorphin-derived peptides from neurointermediate lobe.
Negative_regulation (decreased) of Positive_regulation (levels) of Met-enkephalin in lobe associated with nicotine and enkephalin
18) Confidence 0.42 Published 1987 Journal Peptides Section Abstract Doc Link 3441443 Disease Relevance 0.08 Pain Relevance 1.62
This regimen of nicotine also decreased levels of native Met-enkephalin and of both native and cryptic Leu-enkephalin in neurointermediate lobe, consistent with nicotine-induced release of both proenkephalin A- and prodynorphin-derived peptides from neurointermediate lobe.
Negative_regulation (decreased) of Positive_regulation (levels) of Leu-enkephalin in lobe associated with nicotine and enkephalin
19) Confidence 0.42 Published 1987 Journal Peptides Section Abstract Doc Link 3441443 Disease Relevance 0.08 Pain Relevance 1.62
Striatal proenkephalin and prodynorphin messenger RNA levels were increased and decreased, respectively, after complete 6-hydroxydopamine lesion.
Negative_regulation (decreased) of Positive_regulation (increased) of proenkephalin
20) Confidence 0.42 Published 1993 Journal Neuroscience Section Abstract Doc Link 8232904 Disease Relevance 0 Pain Relevance 0.76

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