INT171146

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 38
Total Number 39
Disease Relevance 11.41
Pain Relevance 7.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Fig4) Golgi apparatus (Fig4) endoplasmic reticulum (Fig4)
Anatomy Link Frequency
microglia 4
spinal cord 2
external 2
effector T cells 2
juvenile 2
Fig4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 341 100.00 Very High Very High Very High
Spinal cord 126 100.00 Very High Very High Very High
cytokine 102 100.00 Very High Very High Very High
tetrodotoxin 93 100.00 Very High Very High Very High
long-term potentiation 44 100.00 Very High Very High Very High
Inflammatory response 30 98.92 Very High Very High Very High
B1 receptor 1 98.84 Very High Very High Very High
Antihyperalgesic 10 98.72 Very High Very High Very High
intrathecal 71 97.92 Very High Very High Very High
qutenza 134 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 403 100.00 Very High Very High Very High
Aids-related Complex 107 99.58 Very High Very High Very High
Injury 175 98.32 Very High Very High Very High
Diabetes Mellitus 147 97.76 Very High Very High Very High
Lung Injury 58 97.00 Very High Very High Very High
Sepsis 66 96.92 Very High Very High Very High
Ganglion Cysts 123 96.76 Very High Very High Very High
Targeted Disruption 17 96.40 Very High Very High Very High
Congenital Anomalies 12 96.32 Very High Very High Very High
Cancer 74 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The resulting average irradiance and average deviation are shown in Fig. 3
Negative_regulation (deviation) of Gene_expression (shown) of Fig
1) Confidence 0.37 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3000694 Disease Relevance 0 Pain Relevance 0
The resulting average irradiance and average deviation are shown in Fig. 11
Negative_regulation (deviation) of Gene_expression (shown) of Fig
2) Confidence 0.37 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3000694 Disease Relevance 0 Pain Relevance 0
Co-administration of SCH 23390 or sulpiride with amphetamine into the medial olfactory tubercle significantly decreased lever pressing (Fig. 8) with a significant main manipulation effect (F2,7?
Negative_regulation (decreased) of Gene_expression (pressing) of Fig in lever
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806927 Disease Relevance 0 Pain Relevance 0.22
Peripheral pre-administration of bupivacaine (0.25%, 10 min prior to BV injection) completely inhibited BV-induced enhancement of LTP magnitude but not profoundly impaired the LTP induction (Fig. 10A, B).
Negative_regulation (impaired) of Gene_expression (induction) of Fig associated with long-term potentiation
4) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759921 Disease Relevance 0.21 Pain Relevance 0.45
M) was not blocked by gene transcription (Fig. 3A) or protein synthesis (Fig. 3B) inhibitor.
Negative_regulation (inhibitor) of Gene_expression (synthesis) of Fig
5) Confidence 0.28 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1201169 Disease Relevance 0 Pain Relevance 0.07
The numbers of cells in the clusters decreased over time, whereas type II collagen and GAG production increased (Fig. 3).
Negative_regulation (decreased) of Gene_expression (production) of Fig
6) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923611 Disease Relevance 0 Pain Relevance 0
Our data revealed that the 8 mM (1ml/250g b.wt., i.p.) dose diminished AA-NAT mRNA expression to about ~5-15% of its postburn expression whereas the 2 mM (1ml/250g b.wt., i.p.) dose decreased it only to 70-80% its postburn expression (Fig. 1C).


Negative_regulation (decreased) of Gene_expression (expression) of Fig
7) Confidence 0.25 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2878173 Disease Relevance 0.23 Pain Relevance 0.05
Indeed, in cells from slices from juvenile rats treated with TTX Elvax, there was a significant increase in the mEPSC amplitude (Control: 21.0±0.9 pA, TTX: 24.2±1.2 pA; Fig 3A; control: n?
Negative_regulation (21.0) of Gene_expression (0.9) of Fig in juvenile associated with tetrodotoxin
8) Confidence 0.20 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933594 Disease Relevance 0 Pain Relevance 0.99
These changes were most likely due to effects on the autoaggressive effector T cells: TMBP-GFP cells within the CNS showed strongly diminished expression of pro-inflammatory cytokines (Fig. 4D).
Negative_regulation (diminished) of Gene_expression (expression) of Fig in effector T cells associated with inflammation, cytokine and spinal cord
9) Confidence 0.18 Published 2010 Journal Brain Section Body Doc Link PMC2892943 Disease Relevance 0.31 Pain Relevance 0.45
BW-B 70C treatment reduced the IR injury-induced inflammatory response by down-regulating iNOS expression (Fig. 3A iii) via inhibition of iNOS gene expression (Fig. 3B).
Negative_regulation (inhibition) of Gene_expression (expression) of Fig associated with inflammatory response and injury
10) Confidence 0.13 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.55 Pain Relevance 0.10
Consistent with the loss of TRPV1 expressing central nerve terminals, the immunoreactivity of CGRP and SP associated with TRPV1 immunoreactivity was also significantly reduced (p<0.001) (Fig. 6E, F).
Negative_regulation (reduced) of Gene_expression (expressing) of Fig in nerve
11) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0.70 Pain Relevance 0.56
Such effect was very evident after 3 hours of treatment, improved in the following 9 hours and slightly decreased after 24 hours (Fig. 2b and 2c, respectively)
Negative_regulation (decreased) of Gene_expression (respectively) of Fig
12) Confidence 0.12 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.07 Pain Relevance 0.43
Fig. 3 shows that sepsis induced TLR4 protein levels and activation, as demonstrated by an increase in TLR4/MyD88 interaction in the three tissues investigated, and atorvastatin reduced this early step of TLR4 activation and also TLR4 expression (Fig. 3A–C).
Negative_regulation (reduced) of Gene_expression (expression) of Fig associated with sepsis
13) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.88 Pain Relevance 0.20
PDTC markedly reduced p65 expression (Fig. 22).
Negative_regulation (reduced) of Gene_expression (expression) of Fig
14) Confidence 0.10 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.17 Pain Relevance 0
Furthermore, BW-B 70C reduced iNOS expression in vitro (Fig. 4B).
Negative_regulation (reduced) of Gene_expression (expression) of Fig
15) Confidence 0.09 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1526713 Disease Relevance 0.80 Pain Relevance 0.17
After changing to specific differentiation medium for astrocytes or neurons and culturing the cells for 7 days, rhNPC appeared to be completely differentiated into astrocytes (Fig. 1C, GFAP as a marker) or neurons (Fig. 1D, ?
Negative_regulation (differentiated) of Gene_expression (neurons) of Fig in astrocytes
16) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677674 Disease Relevance 0.40 Pain Relevance 0.04
The Western blots in Fig. 1A show that the expression of PP2A in the lumbar segments (L3-L6) of the spinal cord tissue was detected at around 36 kDa.
Negative_regulation (detected) of Gene_expression (expression) of Fig in spinal cord associated with spinal cord
17) Confidence 0.08 Published 2006 Journal Mol Pain Section Body Doc Link PMC1456949 Disease Relevance 0.05 Pain Relevance 0.91
Interestingly, the “100 nsec” MB structure in Fig. 4B did not predict any ?
Neg (not) Negative_regulation (predict) of Gene_expression (structure) of Fig
18) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2805716 Disease Relevance 0 Pain Relevance 0
Notably satellite cells under these conditions lacked both CXCR4 mRNA transcripts and protein expression (Fig. 4E, F).
Negative_regulation (lacked) of Gene_expression (expression) of Fig in satellite cells
19) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.29 Pain Relevance 0.18
M) depressed the first EPSP by about the same amount as when external Ca2+ was reduced to 0.8 mM (Fig. 3, top panel, no significant difference, ANOVA, n = 6).
Negative_regulation (reduced) of Neg (no) Gene_expression (panel) of Fig in external
20) Confidence 0.07 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1369004 Disease Relevance 0.25 Pain Relevance 0.43

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