INT171223

Context Info Confidence 0.20 First Reported 2002 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 6 Disease Relevance 3.81 Pain Relevance 0.43

aging (Ncam1) cell adhesion (Ncam1) plasma membrane (Ncam1)

Anatomy Link Frequency neural 2 muscle 1 stage 19 1 NK cells 1 Ncam1 (Mus musculus)

Pain Link Frequency Relevance Heat ischemia 14 84.68 Inflammation 27 78.56 agonist 42 67.52 rheumatoid arthritis 45 67.36 cINOD 1 65.40 withdrawal 2 26.64 metalloproteinase 2 9.44 Inflammatory response 6 7.48 Action potential 22 5.00 depression 8 5.00

Disease Link Frequency Relevance Heat Adhesions 34 100.00 Teratocarcinoma 2 98.64 Hemophagocytic Lymphohistiocytosis 22 87.80 Macrophage Activation Syndrome 29 87.52 Cv Unclassified Under Development 12 84.68 Injury 2 83.44 Aging 4 79.80 INFLAMMATION 34 78.56 Disease 13 77.60 Rheumatoid Arthritis 45 67.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Since muscle inactivity leads to up-regulation of NCAM (Cashman et al. 1987), it is likely to occur after exposure to BoNT/A and may therefore play an important part in stimulating both local and remote sprouting.

Regulation (regulation) of NCAM in muscle

1) Confidence 0.20 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0.17 Pain Relevance 0

positively correlated with modulation of neural cell adhesion molecule (NCAM)

Regulation (modulation) of neural cell adhesion molecule in neural associated with adhesions

2) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2581793 Disease Relevance 1.41 Pain Relevance 0.15

positively correlated with modulation of neural cell adhesion molecule (NCAM)

Regulation (modulation) of NCAM in neural associated with adhesions

3) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2581793 Disease Relevance 1.42 Pain Relevance 0.15

This is known to be true in two of the examples cited above (mdx mice, NCAM up-regulation).

Regulation (regulation) of NCAM

4) Confidence 0.12 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0.11 Pain Relevance 0

In contrast, CD56bright NK cells might have a function in regulating the CD56dim perforinbright cells, and in this case their disappearance might have an effect on cytolytic activity in some sJRA patients.

Regulation (regulating) of CD56dim in NK cells

5) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.70 Pain Relevance 0.14

In PN-1 treated embryos, NCAM immunoreactivity was instead present at stage 19.

Regulation (immunoreactivity) of NCAM in stage 19

6) Confidence 0.07 Published 2002 Journal BMC Dev Biol Section Body Doc Link PMC65692 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.