INT171299

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Context Info
Confidence 0.01
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TNFSF12, MMP1) cell differentiation (TNFSF12) peptidase activity (MMP1)
signal transduction (TNFSF12) extracellular space (TNFSF12) proteinaceous extracellular matrix (MMP1)
Anatomy Link Frequency
fibroblasts 1
TNFSF12 (Homo sapiens)
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 11 73.36 Quite High
Inflammatory mediators 1 59.28 Quite High
Inflammatory response 3 47.92 Quite Low
Inflammation 19 41.28 Quite Low
cytokine 11 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Freund adjuvant 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 21 58.88 Quite High
Adhesions 2 37.52 Quite Low
Death 6 33.60 Quite Low
Disease 8 31.60 Quite Low
Cancer 4 23.52 Low Low
Arthritis 5 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On synoviocytes, but not on dermal fibroblasts, BEB3 alone stimulated the secretion of IL-8, MMP-1 and PGE2, whereas the blocking mAb to TWEAK, BCB10, reduced the basal level of IL-8 and MMP-1, suggesting that synoviocytes secrete endogenous TWEAK.
TWEAK Negative_regulation (reduced) of MMP-1 in fibroblasts
1) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.06 Pain Relevance 0.07

General Comments

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