INT171476

Context Info Confidence 0.42 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.05 Pain Relevance 0.52

plasma membrane (HTR1A) signal transducer activity (HTR1A)

Anatomy Link Frequency neurons 2 HTR1A (Homo sapiens)

Pain Link Frequency Relevance Heat Rostral ventrolateral medulla 2 98.08 Fibrositis 51 97.82 Pain 63 89.20 Neuropeptide 1 74.40 depression 8 63.76 rheumatoid arthritis 1 17.68 Pain score 8 5.00 biopsychosocial 3 5.00 corticosteroid 1 5.00 Pain scale 1 5.00

Disease Link Frequency Relevance Heat Fibromyalgia 51 97.82 Pain 73 89.20 Chronic Disease 1 85.52 Cognitive Disorder 1 73.12 Depression 8 63.76 Neurosis 9 56.52 Anxiety Disorder 8 55.40 Stress 7 49.92 Post-traumatic Stress Disorder 1 35.84 Chronic Fatigue Syndrome 1 23.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

One possible explanation for this finding is that fibromyalgia patients display perturbations in central sympathetic system with reduced reactivity, which might be due to reduced sensitivity of 5-HT1A receptors on sympathoexcitatory neurons in the rostral ventrolateral medulla.

Negative_regulation (reduced) of Regulation (sensitivity) of 5-HT1A in neurons associated with rostral ventrolateral medulla and fibrositis

1) Confidence 0.42 Published 2002 Journal BMC Musculoskelet Disord Section Body Doc Link PMC113754 Disease Relevance 1.05 Pain Relevance 0.52

General Comments

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